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A Tlr7 translocation accelerates systemic autoimmunity in murine lupus.
Subramanian S, Tus K, Li QZ, Wang A, Tian XH, Zhou J, Liang C, Bartov G, McDaniel LD, Zhou XJ, Schultz RA, Wakeland EK. Subramanian S, et al. Among authors: wang a. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9970-5. doi: 10.1073/pnas.0603912103. Epub 2006 Jun 15. Proc Natl Acad Sci U S A. 2006. PMID: 16777955 Free PMC article.
Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice.
Fairhurst AM, Mathian A, Connolly JE, Wang A, Gray HF, George TA, Boudreaux CD, Zhou XJ, Li QZ, Koutouzov S, Banchereau J, Wakeland EK. Fairhurst AM, et al. Among authors: wang a. Eur J Immunol. 2008 Jul;38(7):1948-60. doi: 10.1002/eji.200837925. Eur J Immunol. 2008. PMID: 18506882 Free PMC article.
Yaa autoimmune phenotypes are conferred by overexpression of TLR7.
Fairhurst AM, Hwang SH, Wang A, Tian XH, Boudreaux C, Zhou XJ, Casco J, Li QZ, Connolly JE, Wakeland EK. Fairhurst AM, et al. Among authors: wang a. Eur J Immunol. 2008 Jul;38(7):1971-8. doi: 10.1002/eji.200838138. Eur J Immunol. 2008. PMID: 18521959 Free PMC article.
KLF13 promotes SLE pathogenesis by modifying chromatin accessibility of key proinflammatory cytokine genes.
Wang A, Fairhurst AM, Liu K, Wakeland B, Barnes S, Malladi VS, Viswanathan K, Arana C, Dozmorov I, Singhar A, Du Y, Imam M, Moses A, Chen C, Sunkavalli A, Casco J, Rakheja D, Li QZ, Mohan C, Clayberger C, Wakeland EK, Khan S. Wang A, et al. Commun Biol. 2024 Nov 6;7(1):1446. doi: 10.1038/s42003-024-07099-0. Commun Biol. 2024. PMID: 39506084 Free PMC article.
The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions.
Young JA, Becker AM, Medeiros JJ, Shapiro VS, Wang A, Farrar JD, Quill TA, Hooft van Huijsduijnen R, van Oers NS. Young JA, et al. Among authors: wang a. Mol Immunol. 2008 Aug;45(14):3756-66. doi: 10.1016/j.molimm.2008.05.023. Epub 2008 Jul 9. Mol Immunol. 2008. PMID: 18614237 Free PMC article.
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