Beck-Sickinger A - Search Results

1

Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor.

Holst B, Lang M, Brandt E, Bach A, Howard A, Frimurer TM, Beck-Sickinger A, Schwartz TW. Holst B, et al. Mol Pharmacol. 2006 Sep;70(3):936-46. doi: 10.1124/mol.106.024422. Epub 2006 Jun 23. Mol Pharmacol. 2006. PMID: 16798937

2

Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism.

Holst B, Mokrosinski J, Lang M, Brandt E, Nygaard R, Frimurer TM, Beck-Sickinger AG, Schwartz TW. Holst B, et al. J Biol Chem. 2007 May 25;282(21):15799-811. doi: 10.1074/jbc.M609796200. Epub 2007 Mar 19. J Biol Chem. 2007. PMID: 17371869 Free article.

3

Unique interaction pattern for a functionally biased ghrelin receptor agonist.

Sivertsen B, Lang M, Frimurer TM, Holliday ND, Bach A, Els S, Engelstoft MS, Petersen PS, Madsen AN, Schwartz TW, Beck-Sickinger AG, Holst B. Sivertsen B, et al. J Biol Chem. 2011 Jun 10;286(23):20845-60. doi: 10.1074/jbc.M110.173237. Epub 2011 Mar 14. J Biol Chem. 2011. PMID: 21402696 Free PMC article.

4

In vivo characterization of high Basal signaling from the ghrelin receptor.

Petersen PS, Woldbye DP, Madsen AN, Egerod KL, Jin C, Lang M, Rasmussen M, Beck-Sickinger AG, Holst B. Petersen PS, et al. Endocrinology. 2009 Nov;150(11):4920-30. doi: 10.1210/en.2008-1638. Epub 2009 Oct 9. Endocrinology. 2009. PMID: 19819980

5

An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor.

Els S, Schild E, Petersen PS, Kilian TM, Mokrosinski J, Frimurer TM, Chollet C, Schwartz TW, Holst B, Beck-Sickinger AG. Els S, et al. J Med Chem. 2012 Sep 13;55(17):7437-49. doi: 10.1021/jm300414b. Epub 2012 Sep 5. J Med Chem. 2012. PMID: 22920150

6

Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics.

Park M, Sivertsen BB, Els-Heindl S, Huber T, Holst B, Beck-Sickinger AG, Schwartz TW, Sakmar TP. Park M, et al. Chem Biol. 2015 Nov 19;22(11):1431-1436. doi: 10.1016/j.chembiol.2015.09.014. Epub 2015 Nov 5. Chem Biol. 2015. PMID: 26548612

7

GPR39 signaling is stimulated by zinc ions but not by obestatin.

Holst B, Egerod KL, Schild E, Vickers SP, Cheetham S, Gerlach LO, Storjohann L, Stidsen CE, Jones R, Beck-Sickinger AG, Schwartz TW. Holst B, et al. Endocrinology. 2007 Jan;148(1):13-20. doi: 10.1210/en.2006-0933. Epub 2006 Sep 7. Endocrinology. 2007. PMID: 16959833

8

Structure-activity relationship studies: methods and ligand design for G-protein coupled peptide receptors.

Lang M, Beck-Sickinger AG. Lang M, et al. Curr Protein Pept Sci. 2006 Aug;7(4):335-53. doi: 10.2174/138920306778017981. Curr Protein Pept Sci. 2006. PMID: 16918448 Review.

9

High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice.

Thieme V, Jolly N, Madsen AN, Bellmann-Sickert K, Schwartz TW, Holst B, Cox HM, Beck-Sickinger AG. Thieme V, et al. Br J Pharmacol. 2016 Nov;173(22):3208-3221. doi: 10.1111/bph.13582. Epub 2016 Oct 5. Br J Pharmacol. 2016. PMID: 27545829 Free PMC article.

10

Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor.

Lang M, De Pol S, Baldauf C, Hofmann HJ, Reiser O, Beck-Sickinger AG. Lang M, et al. J Med Chem. 2006 Jan 26;49(2):616-24. doi: 10.1021/jm050613s. J Med Chem. 2006. PMID: 16420047

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