Jacobson E - Search Results

1

A phase 1/2A trial of STA 5326, an oral interleukin-12/23 inhibitor, in patients with active moderate to severe Crohn's disease.

Burakoff R, Barish CF, Riff D, Pruitt R, Chey WY, Farraye FA, Shafran I, Katz S, Krone CL, Vander Vliet M, Stevens C, Sherman ML, Jacobson E, Bleday R. Burakoff R, et al. Among authors: jacobson e. Inflamm Bowel Dis. 2006 Jul;12(7):558-65. doi: 10.1097/01.ibd.0000225337.14356.31. Inflamm Bowel Dis. 2006. PMID: 16804392 Clinical Trial.

2

Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease.

Sands BE, Jacobson EW, Sylwestrowicz T, Younes Z, Dryden G, Fedorak R, Greenbloom S. Sands BE, et al. Among authors: jacobson ew. Inflamm Bowel Dis. 2010 Jul;16(7):1209-18. doi: 10.1002/ibd.21159. Inflamm Bowel Dis. 2010. PMID: 19918967 Clinical Trial.

3

Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis.

Sands BE, Joshi S, Haddad J, Freudenberg JM, Oommen DE, Hoffmann E, McCallum SW, Jacobson E. Sands BE, et al. Among authors: jacobson e. Inflamm Bowel Dis. 2016 Mar;22(3):607-14. doi: 10.1097/MIB.0000000000000597. Inflamm Bowel Dis. 2016. PMID: 26595549 Free PMC article. Clinical Trial.

4

Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.

Wada Y, Cardinale I, Khatcherian A, Chu J, Kantor AB, Gottlieb AB, Tatsuta N, Jacobson E, Barsoum J, Krueger JG. Wada Y, et al. Among authors: jacobson e. PLoS One. 2012;7(4):e35069. doi: 10.1371/journal.pone.0035069. Epub 2012 Apr 6. PLoS One. 2012. PMID: 22493730 Free PMC article. Clinical Trial.

5

Brief report: a phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an interleukin-12/interleukin-23 inhibitor, in patients with rheumatoid arthritis.

Krausz S, Boumans MJ, Gerlag DM, Lufkin J, van Kuijk AW, Bakker A, de Boer M, Lodde BM, Reedquist KA, Jacobson EW, O'Meara M, Tak PP. Krausz S, et al. Arthritis Rheum. 2012 Jun;64(6):1750-5. doi: 10.1002/art.34339. Epub 2011 Dec 14. Arthritis Rheum. 2012. PMID: 22170479 Free article. Clinical Trial.

6

A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis.

Krueger JG, Suárez-Fariñas M, Cueto I, Khacherian A, Matheson R, Parish LC, Leonardi C, Shortino D, Gupta A, Haddad J, Vlasuk GP, Jacobson EW. Krueger JG, et al. PLoS One. 2015 Nov 10;10(11):e0142081. doi: 10.1371/journal.pone.0142081. eCollection 2015. PLoS One. 2015. PMID: 26556603 Free PMC article. Clinical Trial.

7

gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial.

Zurier RB, Rossetti RG, Jacobson EW, DeMarco DM, Liu NY, Temming JE, White BM, Laposata M. Zurier RB, et al. Among authors: jacobson ew. Arthritis Rheum. 1996 Nov;39(11):1808-17. doi: 10.1002/art.1780391106. Arthritis Rheum. 1996. PMID: 8912502 Clinical Trial.

8

A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes.

Baksi A, Kraydashenko O, Zalevkaya A, Stets R, Elliott P, Haddad J, Hoffmann E, Vlasuk GP, Jacobson EW. Baksi A, et al. Among authors: jacobson ew. Br J Clin Pharmacol. 2014 Jul;78(1):69-77. doi: 10.1111/bcp.12327. Br J Clin Pharmacol. 2014. PMID: 24446723 Free PMC article. Clinical Trial.

9

Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man.

Hoffmann E, Wald J, Lavu S, Roberts J, Beaumont C, Haddad J, Elliott P, Westphal C, Jacobson E. Hoffmann E, et al. Among authors: jacobson e. Br J Clin Pharmacol. 2013 Jan;75(1):186-96. doi: 10.1111/j.1365-2125.2012.04340.x. Br J Clin Pharmacol. 2013. PMID: 22616762 Free PMC article. Clinical Trial.

10

Cardiovascular effects of a novel SIRT1 activator, SRT2104, in otherwise healthy cigarette smokers.

Venkatasubramanian S, Noh RM, Daga S, Langrish JP, Joshi NV, Mills NL, Hoffmann E, Jacobson EW, Vlasuk GP, Waterhouse BR, Lang NN, Newby DE. Venkatasubramanian S, et al. Among authors: jacobson ew. J Am Heart Assoc. 2013 Jun 14;2(3):e000042. doi: 10.1161/JAHA.113.000042. J Am Heart Assoc. 2013. PMID: 23770971 Free PMC article. Clinical Trial.

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