Wu D - Search Results

1

Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1.

Rowbottom MW, Vickers TD, Dyck B, Grey J, Tamiya J, Zhang M, Kiankarimi M, Wu D, Dwight W, Wade WS, Schwarz D, Heise CE, Madan A, Fisher A, Petroski R, Goodfellow VS. Rowbottom MW, et al. Among authors: wu d. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4450-7. doi: 10.1016/j.bmcl.2006.06.045. Epub 2006 Jun 30. Bioorg Med Chem Lett. 2006. PMID: 16814542

2

Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.

Zhu YF, Guo Z, Gross TD, Gao Y, Connors PJ Jr, Struthers RS, Xie Q, Tucci FC, Reinhart GJ, Wu D, Saunders J, Chen C. Zhu YF, et al. Among authors: wu d. J Med Chem. 2003 Apr 24;46(9):1769-72. doi: 10.1021/jm0205402. J Med Chem. 2003. PMID: 12699396

3

Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidine-2,4-dione derivatives as potent GnRH receptor antagonists.

Guo Z, Chen Y, Wu D, Zhu YF, Struthers RS, Saunders J, Xie Q, Chen C. Guo Z, et al. Among authors: wu d. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3617-22. doi: 10.1016/s0960-894x(03)00746-7. Bioorg Med Chem Lett. 2003. PMID: 14505682

4

A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists.

Guo Z, Wu D, Zhu YF, Tucci FC, Pontillo J, Saunders J, Xie Q, Struthers RS, Chen C. Guo Z, et al. Among authors: wu d. Bioorg Med Chem Lett. 2005 Feb 1;15(3):693-8. doi: 10.1016/j.bmcl.2004.11.026. Bioorg Med Chem Lett. 2005. PMID: 15664839

5

Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers.

Guo Z, Chen Y, Huang CQ, Gross TD, Pontillo J, Rowbottom MW, Saunders J, Struthers S, Tucci FC, Xie Q, Wade W, Zhu YF, Wu D, Chen C. Guo Z, et al. Among authors: wu d. Bioorg Med Chem Lett. 2005 May 16;15(10):2519-22. doi: 10.1016/j.bmcl.2005.03.057. Bioorg Med Chem Lett. 2005. PMID: 15863308

6

Structure-activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists.

Guo Z, Wu D, Zhu YF, Tucci FC, Regan CF, Rowbottom MW, Struthers RS, Xie Q, Reijmers S, Sullivan SK, Sai Y, Chen C. Guo Z, et al. Among authors: wu d. Bioorg Med Chem Lett. 2005 Aug 15;15(16):3685-90. doi: 10.1016/j.bmcl.2005.05.038. Bioorg Med Chem Lett. 2005. PMID: 15951171

7

Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor.

Pontillo J, Guo Z, Wu D, Struthers RS, Chen C. Pontillo J, et al. Among authors: wu d. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4363-6. doi: 10.1016/j.bmcl.2005.06.057. Bioorg Med Chem Lett. 2005. PMID: 16046130

8

Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2.

Hudson S, Kiankarimi M, Rowbottom MW, Vickers TD, Wu D, Pontillo J, Ching B, Dwight W, Goodfellow VS, Schwarz D, Heise CE, Madan A, Wen J, Ban W, Wang H, Wade WS. Hudson S, et al. Among authors: wu d. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4922-30. doi: 10.1016/j.bmcl.2006.06.049. Epub 2006 Jul 7. Bioorg Med Chem Lett. 2006. PMID: 16824755

9

5-Aryluracils as potent GnRH antagonists-Characterization of atropisomers.

Zhao L, Guo Z, Chen Y, Hu T, Wu D, Zhu YF, Rowbottom M, Gross TD, Tucci FC, Struthers RS, Xie Q, Chen C. Zhao L, et al. Among authors: wu d. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3344-9. doi: 10.1016/j.bmcl.2008.04.029. Epub 2008 Apr 15. Bioorg Med Chem Lett. 2008. PMID: 18442905

10

Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity.

Chen C, Chen Y, Pontillo J, Guo Z, Huang CQ, Wu D, Madan A, Chen T, Wen J, Xie Q, Tucci FC, Rowbottom M, Zhu YF, Wade W, Saunders J, Bozigian H, Struthers RS. Chen C, et al. Among authors: wu d. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3301-5. doi: 10.1016/j.bmcl.2008.04.036. Epub 2008 Apr 26. Bioorg Med Chem Lett. 2008. PMID: 18442910

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