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Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival.
Janmaat S, Akwa Y, Doulazmi M, Bakouche J, Gautheron V, Liere P, Eychenne B, Pianos A, Luiten P, Groothuis T, Baulieu EE, Mariani J, Sherrard RM, Frédéric F. Janmaat S, et al. Among authors: doulazmi m. Age (Dordr). 2011 Dec;33(4):565-78. doi: 10.1007/s11357-010-9203-3. Epub 2011 Jan 11. Age (Dordr). 2011. PMID: 21222044 Free PMC article.
Thyroid hormone triggers the developmental loss of axonal regenerative capacity via thyroid hormone receptor α1 and krüppel-like factor 9 in Purkinje cells.
Avci HX, Lebrun C, Wehrlé R, Doulazmi M, Chatonnet F, Morel MP, Ema M, Vodjdani G, Sotelo C, Flamant F, Dusart I. Avci HX, et al. Among authors: doulazmi m. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14206-11. doi: 10.1073/pnas.1119853109. Epub 2012 Aug 13. Proc Natl Acad Sci U S A. 2012. PMID: 22891348 Free PMC article.
54 results