Love R - Search Results

1

Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors.

Li H, Tatlock J, Linton A, Gonzalez J, Borchardt A, Dragovich P, Jewell T, Prins T, Zhou R, Blazel J, Parge H, Love R, Hickey M, Doan C, Shi S, Duggal R, Lewis C, Fuhrman S. Li H, et al. Among authors: love r. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4834-8. doi: 10.1016/j.bmcl.2006.06.065. Epub 2006 Jul 7. Bioorg Med Chem Lett. 2006. PMID: 16824756

2

Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme.

Love RA, Parge HE, Yu X, Hickey MJ, Diehl W, Gao J, Wriggers H, Ekker A, Wang L, Thomson JA, Dragovich PS, Fuhrman SA. Love RA, et al. J Virol. 2003 Jul;77(13):7575-81. doi: 10.1128/jvi.77.13.7575-7581.2003. J Virol. 2003. PMID: 12805457 Free PMC article.

3

The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy.

Love RA, Maegley KA, Yu X, Ferre RA, Lingardo LK, Diehl W, Parge HE, Dragovich PS, Fuhrman SA. Love RA, et al. Structure. 2004 Aug;12(8):1533-44. doi: 10.1016/j.str.2004.05.024. Structure. 2004. PMID: 15296746 Free article.

4

Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus.

Love RA, Brodsky O, Hickey MJ, Wells PA, Cronin CN. Love RA, et al. J Virol. 2009 May;83(9):4395-403. doi: 10.1128/JVI.02352-08. Epub 2009 Feb 25. J Virol. 2009. PMID: 19244328 Free PMC article.

5

Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.

Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, Hendrickson TF, Love RA, Prins TJ, Marakovits JT, Zhou R, Tikhe J, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, Brothers MA, DeLisle DM, Worland ST. Matthews DA, et al. Among authors: love ra. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7. doi: 10.1073/pnas.96.20.11000. Proc Natl Acad Sci U S A. 1999. PMID: 10500114 Free PMC article.

6

Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements.

Webber SE, Okano K, Little TL, Reich SH, Xin Y, Fuhrman SA, Matthews DA, Love RA, Hendrickson TF, Patick AK, Meador JW 3rd, Ferre RA, Brown EL, Ford CE, Binford SL, Worland ST. Webber SE, et al. Among authors: love ra. J Med Chem. 1998 Jul 16;41(15):2786-805. doi: 10.1021/jm980071x. J Med Chem. 1998. PMID: 9667969

7

Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease.

Webber SE, Tikhe J, Worland ST, Fuhrman SA, Hendrickson TF, Matthews DA, Love RA, Patick AK, Meador JW, Ferre RA, Brown EL, DeLisle DM, Ford CE, Binford SL. Webber SE, et al. Among authors: love ra. J Med Chem. 1996 Dec 20;39(26):5072-82. doi: 10.1021/jm960603e. J Med Chem. 1996. PMID: 8978838

8

The conformation of hepatitis C virus NS3 proteinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor.

Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, Adachi T, Margosiak S, Dagostino E, Hostomska Z. Love RA, et al. Clin Diagn Virol. 1998 Jul 15;10(2-3):151-6. doi: 10.1016/s0928-0197(98)00036-1. Clin Diagn Virol. 1998. PMID: 9741640

9

Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.

Himmel DM, Maegley KA, Pauly TA, Bauman JD, Das K, Dharia C, Clark AD Jr, Ryan K, Hickey MJ, Love RA, Hughes SH, Bergqvist S, Arnold E. Himmel DM, et al. Structure. 2009 Dec 9;17(12):1625-1635. doi: 10.1016/j.str.2009.09.016. Structure. 2009. PMID: 20004166 Free PMC article.

10

The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site.

Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, Adachi T, Hostomska Z. Love RA, et al. Cell. 1996 Oct 18;87(2):331-42. doi: 10.1016/s0092-8674(00)81350-1. Cell. 1996. PMID: 8861916 Free article.

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