The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation.
Russell DS, Gherzi R, Johnson EL, Chou CK, Rosen OM.
Russell DS, et al. Among authors: chou ck.
J Biol Chem. 1987 Aug 25;262(24):11833-40.
J Biol Chem. 1987.
PMID: 2957374
Free article.
We have previously demonstrated that the human insulin receptor, mutated in the ATP-binding domain of the beta-subunit, is kinase-defective and fails to mediate multiple post-receptor actions of insulin in stably transfected Chinese hamster ovary cells (Chou, C.-K., …
We have previously demonstrated that the human insulin receptor, mutated in the ATP-binding domain of the beta-subunit, is kinase-defective …