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Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening.
Schürer SC, Brown SJ, Gonzalez-Cabrera PJ, Schaeffer MT, Chapman J, Jo E, Chase P, Spicer T, Hodder P, Rosen H. Schürer SC, et al. Among authors: jo e. ACS Chem Biol. 2008 Aug 15;3(8):486-98. doi: 10.1021/cb800051m. Epub 2008 Jul 1. ACS Chem Biol. 2008. PMID: 18590333 Free PMC article.
S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF.
Gon Y, Wood MR, Kiosses WB, Jo E, Sanna MG, Chun J, Rosen H. Gon Y, et al. Among authors: jo e. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9270-5. doi: 10.1073/pnas.0501997102. Epub 2005 Jun 20. Proc Natl Acad Sci U S A. 2005. Retraction in: Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12561. doi: 10.1073/pnas.0907125106 PMID: 15968000 Free PMC article. Retracted.
Novel selective allosteric and bitopic ligands for the S1P(3) receptor.
Jo E, Bhhatarai B, Repetto E, Guerrero M, Riley S, Brown SJ, Kohno Y, Roberts E, Schürer SC, Rosen H. Jo E, et al. ACS Chem Biol. 2012 Dec 21;7(12):1975-83. doi: 10.1021/cb300392z. Epub 2012 Sep 14. ACS Chem Biol. 2012. PMID: 22971058 Free PMC article.
Crystal structure of a lipid G protein-coupled receptor.
Hanson MA, Roth CB, Jo E, Griffith MT, Scott FL, Reinhart G, Desale H, Clemons B, Cahalan SM, Schuerer SC, Sanna MG, Han GW, Kuhn P, Rosen H, Stevens RC. Hanson MA, et al. Among authors: jo e. Science. 2012 Feb 17;335(6070):851-5. doi: 10.1126/science.1215904. Science. 2012. PMID: 22344443 Free PMC article.
875 results