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Celecoxib treatment alters the gene expression profile of normal colonic mucosa.
Glebov OK, Rodriguez LM, Lynch P, Patterson S, Lynch H, Nakahara K, Jenkins J, Cliatt J, Humbyrd CJ, Denobile J, Soballe P, Gallinger S, Buchbinder A, Gordon G, Hawk E, Kirsch IR. Glebov OK, et al. Among authors: kirsch ir. Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1382-91. doi: 10.1158/1055-9965.EPI-04-0866. Cancer Epidemiol Biomarkers Prev. 2006. PMID: 16835340 Clinical Trial.
Distinguishing right from left colon by the pattern of gene expression.
Glebov OK, Rodriguez LM, Nakahara K, Jenkins J, Cliatt J, Humbyrd CJ, DeNobile J, Soballe P, Simon R, Wright G, Lynch P, Patterson S, Lynch H, Gallinger S, Buchbinder A, Gordon G, Hawk E, Kirsch IR. Glebov OK, et al. Among authors: kirsch ir. Cancer Epidemiol Biomarkers Prev. 2003 Aug;12(8):755-62. Cancer Epidemiol Biomarkers Prev. 2003. PMID: 12917207
Chromosomal instability is associated with higher expression of genes implicated in epithelial-mesenchymal transition, cancer invasiveness, and metastasis and with lower expression of genes involved in cell cycle checkpoints, DNA repair, and chromatin maintenance.
Roschke AV, Glebov OK, Lababidi S, Gehlhaus KS, Weinstein JN, Kirsch IR. Roschke AV, et al. Among authors: kirsch ir. Neoplasia. 2008 Nov;10(11):1222-30. doi: 10.1593/neo.08682. Neoplasia. 2008. PMID: 18953431 Free PMC article.
188 results