Nassar N - Search Results

1

Structure-function based design of small molecule inhibitors targeting Rho family GTPases.

Nassar N, Cancelas J, Zheng J, Williams DA, Zheng Y. Nassar N, et al. Curr Top Med Chem. 2006;6(11):1109-16. doi: 10.2174/156802606777812095. Curr Top Med Chem. 2006. PMID: 16842149 Review.

2

Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia.

Hegde S, Gasilina A, Wunderlich M, Lin Y, Buchholzer M, Krumbach OHF, Akbarzadeh M, Ahmadian MR, Seibel W, Zheng Y, Perentesis JP, Mizukawa BE, Vinnedge LP, Cancelas JA, Nassar NN. Hegde S, et al. Among authors: nassar nn. Leukemia. 2022 Mar;36(3):637-647. doi: 10.1038/s41375-021-01455-3. Epub 2021 Oct 28. Leukemia. 2022. PMID: 34711926 Free PMC article.

3

IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models.

Gasilina A, Premnauth G, Gurjar P, Biesiada J, Hegde S, Milewski D, Ma G, Kalin TV, Merino E, Meller J, Seibel W, Cancelas JA, Vinnedge LP, Nassar NN. Gasilina A, et al. Among authors: nassar nn. PLoS One. 2020 Mar 12;15(3):e0229801. doi: 10.1371/journal.pone.0229801. eCollection 2020. PLoS One. 2020. PMID: 32163428 Free PMC article.

4

Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization.

Liu W, Du W, Shang X, Wang L, Evelyn C, Florian MC, A Ryan M, Rayes A, Zhao X, Setchell K, Meller J, Guo F, Nassar N, Geiger H, Pang Q, Zheng Y. Liu W, et al. Among authors: nassar n. Leukemia. 2019 Mar;33(3):749-761. doi: 10.1038/s41375-018-0251-5. Epub 2018 Sep 25. Leukemia. 2019. PMID: 30254339 Free PMC article.

5

The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids.

Skowronek KR, Guo F, Zheng Y, Nassar N. Skowronek KR, et al. Among authors: nassar n. J Biol Chem. 2004 Sep 3;279(36):37895-907. doi: 10.1074/jbc.M312677200. Epub 2004 Jun 15. J Biol Chem. 2004. PMID: 15199069 Free article.

6

Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis.

Nayak RC, Chang KH, Singh AK, Kotliar M, Desai M, Wellendorf AM, Wunderlich M, Bartram J, Mizukawa B, Cuadrado M, Dexheimer P, Barski A, Bustelo XR, Nassar NN, Cancelas JA. Nayak RC, et al. Among authors: nassar nn. Nat Commun. 2022 Jun 1;13(1):3056. doi: 10.1038/s41467-022-30651-7. Nat Commun. 2022. PMID: 35650206 Free PMC article.

7

Crystallization and initial crystal characterization of the N-terminal DH/PH domain of Trio.

Skowronek K, Ghumman M, Zheng Y, Nassar N. Skowronek K, et al. Among authors: nassar n. Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1273-5. doi: 10.1107/s0907444903009442. Epub 2003 Jun 27. Acta Crystallogr D Biol Crystallogr. 2003. PMID: 12832783

8

Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI.

Hoffman GR, Nassar N, Cerione RA. Hoffman GR, et al. Among authors: nassar n. Cell. 2000 Feb 4;100(3):345-56. doi: 10.1016/s0092-8674(00)80670-4. Cell. 2000. PMID: 10676816 Free article.

9

Stacking the DEK: from chromatin topology to cancer stem cells.

Privette Vinnedge LM, Kappes F, Nassar N, Wells SI. Privette Vinnedge LM, et al. Among authors: nassar n. Cell Cycle. 2013 Jan 1;12(1):51-66. doi: 10.4161/cc.23121. Epub 2012 Dec 19. Cell Cycle. 2013. PMID: 23255114 Free PMC article. Review.

10

Fluoride activation of the Rho family GTP-binding protein Cdc42Hs.

Hoffman GR, Nassar N, Oswald RE, Cerione RA. Hoffman GR, et al. Among authors: nassar n. J Biol Chem. 1998 Feb 20;273(8):4392-9. doi: 10.1074/jbc.273.8.4392. J Biol Chem. 1998. PMID: 9468490 Free article.

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