Cantley LC - Search Results

1

The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors.

Engelman JA, Cantley LC. Engelman JA, et al. Among authors: cantley lc. Clin Cancer Res. 2006 Jul 15;12(14 Pt 2):4372s-4376s. doi: 10.1158/1078-0432.CCR-06-0795. Clin Cancer Res. 2006. PMID: 16857813 Review.

2

Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.

Brachmann SM, Ueki K, Engelman JA, Kahn RC, Cantley LC. Brachmann SM, et al. Among authors: cantley lc. Mol Cell Biol. 2005 Mar;25(5):1596-607. doi: 10.1128/MCB.25.5.1596-1607.2005. Mol Cell Biol. 2005. PMID: 15713620 Free PMC article.

3

ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines.

Engelman JA, Jänne PA, Mermel C, Pearlberg J, Mukohara T, Fleet C, Cichowski K, Johnson BE, Cantley LC. Engelman JA, et al. Among authors: cantley lc. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3788-93. doi: 10.1073/pnas.0409773102. Epub 2005 Feb 24. Proc Natl Acad Sci U S A. 2005. PMID: 15731348 Free PMC article.

4

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex.

Luo J, Field SJ, Lee JY, Engelman JA, Cantley LC. Luo J, et al. Among authors: cantley lc. J Cell Biol. 2005 Aug 1;170(3):455-64. doi: 10.1083/jcb.200503088. Epub 2005 Jul 25. J Cell Biol. 2005. PMID: 16043515 Free PMC article.

5

Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations.

Mukohara T, Engelman JA, Hanna NH, Yeap BY, Kobayashi S, Lindeman N, Halmos B, Pearlberg J, Tsuchihashi Z, Cantley LC, Tenen DG, Johnson BE, Jänne PA. Mukohara T, et al. Among authors: cantley lc. J Natl Cancer Inst. 2005 Aug 17;97(16):1185-94. doi: 10.1093/jnci/dji238. J Natl Cancer Inst. 2005. PMID: 16106023

6

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells.

Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS. Isakoff SJ, et al. Among authors: cantley lc. Cancer Res. 2005 Dec 1;65(23):10992-1000. doi: 10.1158/0008-5472.CAN-05-2612. Cancer Res. 2005. PMID: 16322248

7

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.

Engelman JA, Luo J, Cantley LC. Engelman JA, et al. Among authors: cantley lc. Nat Rev Genet. 2006 Aug;7(8):606-19. doi: 10.1038/nrg1879. Nat Rev Genet. 2006. PMID: 16847462 Review.

8

Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer.

Engelman JA, Mukohara T, Zejnullahu K, Lifshits E, Borrás AM, Gale CM, Naumov GN, Yeap BY, Jarrell E, Sun J, Tracy S, Zhao X, Heymach JV, Johnson BE, Cantley LC, Jänne PA. Engelman JA, et al. Among authors: cantley lc. J Clin Invest. 2006 Oct;116(10):2695-706. doi: 10.1172/JCI28656. Epub 2006 Aug 10. J Clin Invest. 2006. PMID: 16906227 Free PMC article.

9

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.

Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Jänne PA. Engelman JA, et al. Among authors: cantley lc. Science. 2007 May 18;316(5827):1039-43. doi: 10.1126/science.1141478. Epub 2007 Apr 26. Science. 2007. PMID: 17463250

10

Biochemistry. PI3K charges ahead.

Lee JY, Engelman JA, Cantley LC. Lee JY, et al. Among authors: cantley lc. Science. 2007 Jul 13;317(5835):206-7. doi: 10.1126/science.1146073. Science. 2007. PMID: 17626872 No abstract available.

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