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Fetal liver X receptor activation acutely induces lipogenesis but does not affect plasma lipid response to a high-fat diet in adult mice.
van Straten EM, van Meer H, Huijkman NC, van Dijk TH, Baller JF, Verkade HJ, Kuipers F, Plösch T. van Straten EM, et al. Among authors: huijkman nc. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1171-8. doi: 10.1152/ajpendo.00021.2009. Epub 2009 Sep 1. Am J Physiol Endocrinol Metab. 2009. PMID: 19724022 Free article.
NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.
Riedlinger T, Dommerholt MB, Wijshake T, Kruit JK, Huijkman N, Dekker D, Koster M, Kloosterhuis N, Koonen DPY, de Bruin A, Baker D, Hofker MH, van Deursen J, Jonker JW, Schmitz ML, van de Sluis B. Riedlinger T, et al. Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1785-1798. doi: 10.1016/j.bbamcr.2017.07.005. Epub 2017 Jul 16. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28723419 Free article.
The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance.
Wijers M, Zanoni P, Liv N, Vos DY, Jäckstein MY, Smit M, Wilbrink S, Wolters JC, van der Veen YT, Huijkman N, Dekker D, Kloosterhuis N, van Dijk TH, Billadeau DD, Kuipers F, Klumperman J, von Eckardstein A, Kuivenhoven JA, van de Sluis B. Wijers M, et al. JCI Insight. 2019 Jun 6;4(11):e126462. doi: 10.1172/jci.insight.126462. eCollection 2019 Jun 6. JCI Insight. 2019. PMID: 31167970 Free PMC article.
FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements.
van Zutphen T, Stroeve JHM, Yang J, Bloks VW, Jurdzinski A, Roelofsen H, Huijkman NCA, van Dijk TH, Vonk RJ, van Deursen J, Staels B, Groen AK, Kuipers F. van Zutphen T, et al. Among authors: huijkman nca. J Lipid Res. 2019 Sep;60(9):1547-1561. doi: 10.1194/jlr.M094508. Epub 2019 Jun 28. J Lipid Res. 2019. PMID: 31253637 Free PMC article.
32 results