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The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway.
Boileau C, Pelletier JP, Tardif G, Fahmi H, Laufer S, Lavigne M, Martel-Pelletier J. Boileau C, et al. Among authors: lavigne m. Ann Rheum Dis. 2005 Jun;64(6):891-8. doi: 10.1136/ard.2004.026906. Epub 2004 Oct 21. Ann Rheum Dis. 2005. PMID: 15498796 Free PMC article.
Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids.
Martel-Pelletier J, Mineau F, Fahmi H, Laufer S, Reboul P, Boileau C, Lavigne M, Pelletier JP. Martel-Pelletier J, et al. Among authors: lavigne m. Arthritis Rheum. 2004 Dec;50(12):3925-33. doi: 10.1002/art.20632. Arthritis Rheum. 2004. PMID: 15593193 Free article.
Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.
Cheng S, Afif H, Martel-Pelletier J, Pelletier JP, Li X, Farrajota K, Lavigne M, Fahmi H. Cheng S, et al. Among authors: lavigne m. J Biol Chem. 2004 May 21;279(21):22057-65. doi: 10.1074/jbc.M402828200. Epub 2004 Mar 15. J Biol Chem. 2004. PMID: 15023995 Free article.
The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappaB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells.
Kwan Tat S, Pelletier JP, Lajeunesse D, Fahmi H, Lavigne M, Martel-Pelletier J. Kwan Tat S, et al. Among authors: lavigne m. Clin Exp Rheumatol. 2008 Mar-Apr;26(2):295-304. Clin Exp Rheumatol. 2008. PMID: 18565252 Free PMC article.
235 results