Alao JP - Search Results

1

In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography.

Leyton J, Alao JP, Da Costa M, Stavropoulou AV, Latigo JR, Perumal M, Pillai R, He Q, Atadja P, Lam EW, Workman P, Vigushin DM, Aboagye EO. Leyton J, et al. Among authors: alao jp. Cancer Res. 2006 Aug 1;66(15):7621-9. doi: 10.1158/0008-5472.CAN-05-3962. Cancer Res. 2006. PMID: 16885362

2

Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines.

Alao JP, Lam EW, Ali S, Buluwela L, Bordogna W, Lockey P, Varshochi R, Stavropoulou AV, Coombes RC, Vigushin DM. Alao JP, et al. Clin Cancer Res. 2004 Dec 1;10(23):8094-104. doi: 10.1158/1078-0432.CCR-04-1023. Clin Cancer Res. 2004. PMID: 15585645

3

Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.

Sanderson L, Taylor GW, Aboagye EO, Alao JP, Latigo JR, Coombes RC, Vigushin DM. Sanderson L, et al. Among authors: alao jp. Drug Metab Dispos. 2004 Oct;32(10):1132-8. doi: 10.1124/dmd.104.000638. Epub 2004 Jul 21. Drug Metab Dispos. 2004. PMID: 15269190

4

The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines.

Alao JP, Gamble SC, Stavropoulou AV, Pomeranz KM, Lam EW, Coombes RC, Vigushin DM. Alao JP, et al. Mol Cancer. 2006 Feb 17;5:7. doi: 10.1186/1476-4598-5-7. Mol Cancer. 2006. PMID: 16503970 Free PMC article.

5

Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.

Alao JP, Stavropoulou AV, Lam EW, Coombes RC, Vigushin DM. Alao JP, et al. Mol Cancer. 2006 Feb 20;5:8. doi: 10.1186/1476-4598-5-8. Mol Cancer. 2006. PMID: 16504004 Free PMC article.

6

Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells.

Alao JP, Stavropoulou AV, Lam EW, Coombes RC. Alao JP, et al. Mol Cancer. 2006 Oct 3;5:40. doi: 10.1186/1476-4598-5-40. Mol Cancer. 2006. PMID: 17018141 Free PMC article.

7

ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line.

Varshochi R, Halim F, Sunters A, Alao JP, Madureira PA, Hart SM, Ali S, Vigushin DM, Coombes RC, Lam EW. Varshochi R, et al. Among authors: alao jp. J Biol Chem. 2005 Feb 4;280(5):3185-96. doi: 10.1074/jbc.M408063200. Epub 2004 Nov 19. J Biol Chem. 2005. PMID: 15557281 Free article.

8

Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides.

Marson CM, Serradji N, Rioja AS, Gastaud SP, Alao JP, Coombes RC, Vigushin DM. Marson CM, et al. Among authors: alao jp. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81. doi: 10.1016/j.bmcl.2004.03.012. Bioorg Med Chem Lett. 2004. PMID: 15109636

9

The nuclear oxysterol receptor LXRalpha is expressed in the normal human breast and in breast cancer.

Vigushin DM, Dong Y, Inman L, Peyvandi N, Alao JP, Sun C, Ali S, Niesor EJ, Bentzen CL, Coombes RC. Vigushin DM, et al. Among authors: alao jp. Med Oncol. 2004;21(2):123-31. doi: 10.1385/MO:21:2:123. Med Oncol. 2004. PMID: 15299184

10

Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase.

Marson CM, Mahadevan T, Dines J, Sengmany S, Morrell JM, Alao JP, Joel SP, Vigushin DM, Charles Coombes R. Marson CM, et al. Among authors: alao jp. Bioorg Med Chem Lett. 2007 Jan 1;17(1):136-41. doi: 10.1016/j.bmcl.2006.09.085. Epub 2006 Sep 30. Bioorg Med Chem Lett. 2007. PMID: 17046252

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