Perumal M - Search Results

1

In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography.

Leyton J, Alao JP, Da Costa M, Stavropoulou AV, Latigo JR, Perumal M, Pillai R, He Q, Atadja P, Lam EW, Workman P, Vigushin DM, Aboagye EO. Leyton J, et al. Among authors: perumal m. Cancer Res. 2006 Aug 1;66(15):7621-9. doi: 10.1158/0008-5472.CAN-05-3962. Cancer Res. 2006. PMID: 16885362

2

The uptake of 3'-deoxy-3'-[18F]fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levels.

Barthel H, Perumal M, Latigo J, He Q, Brady F, Luthra SK, Price PM, Aboagye EO. Barthel H, et al. Among authors: perumal m. Eur J Nucl Med Mol Imaging. 2005 Mar;32(3):257-63. doi: 10.1007/s00259-004-1611-0. Epub 2004 Sep 4. Eur J Nucl Med Mol Imaging. 2005. PMID: 15791434

3

Early detection of tumor response to chemotherapy by 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography: the effect of cisplatin on a fibrosarcoma tumor model in vivo.

Leyton J, Latigo JR, Perumal M, Dhaliwal H, He Q, Aboagye EO. Leyton J, et al. Among authors: perumal m. Cancer Res. 2005 May 15;65(10):4202-10. doi: 10.1158/0008-5472.CAN-04-4008. Cancer Res. 2005. PMID: 15899811

4

Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography.

Perumal M, Pillai RG, Barthel H, Leyton J, Latigo JR, Forster M, Mitchell F, Jackman AL, Aboagye EO. Perumal M, et al. Cancer Res. 2006 Sep 1;66(17):8558-64. doi: 10.1158/0008-5472.CAN-06-0898. Cancer Res. 2006. PMID: 16951168

5

Imaging pharmacodynamics of the alpha-folate receptor-targeted thymidylate synthase inhibitor BGC 945.

Pillai RG, Forster M, Perumal M, Mitchell F, Leyton J, Aibgirhio FI, Golovko O, Jackman AL, Aboagye EO. Pillai RG, et al. Among authors: perumal m. Cancer Res. 2008 May 15;68(10):3827-34. doi: 10.1158/0008-5472.CAN-08-0135. Cancer Res. 2008. PMID: 18483267 Free PMC article.

6

Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901.

Leyton J, Smith G, Lees M, Perumal M, Nguyen QD, Aigbirhio FI, Golovko O, He Q, Workman P, Aboagye EO. Leyton J, et al. Among authors: perumal m. Mol Cancer Ther. 2008 Sep;7(9):3112-21. doi: 10.1158/1535-7163.MCT-08-0264. Mol Cancer Ther. 2008. PMID: 18790789

7

[18F]fluoromethyl-[1,2-2H4]-choline: a novel radiotracer for imaging choline metabolism in tumors by positron emission tomography.

Leyton J, Smith G, Zhao Y, Perumal M, Nguyen QD, Robins E, Arstad E, Aboagye EO. Leyton J, et al. Among authors: perumal m. Cancer Res. 2009 Oct 1;69(19):7721-8. doi: 10.1158/0008-5472.CAN-09-1419. Epub 2009 Sep 22. Cancer Res. 2009. PMID: 19773436 Free PMC article.

8

Evaluation of 2-deoxy-2-[18F]fluoro-D-glucose- and 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography as biomarkers of therapy response in platinum-resistant ovarian cancer.

Perumal M, Stronach EA, Gabra H, Aboagye EO. Perumal M, et al. Mol Imaging Biol. 2012 Dec;14(6):753-61. doi: 10.1007/s11307-012-0554-2. Mol Imaging Biol. 2012. PMID: 22484552

9

A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth.

Kaliszczak M, Trousil S, Åberg O, Perumal M, Nguyen QD, Aboagye EO. Kaliszczak M, et al. Among authors: perumal m. Br J Cancer. 2013 Feb 5;108(2):342-50. doi: 10.1038/bjc.2012.576. Epub 2013 Jan 15. Br J Cancer. 2013. PMID: 23322205 Free PMC article.

10

Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity.

Chan F, Sun C, Perumal M, Nguyen QD, Bavetsias V, McDonald E, Martins V, Wilsher NE, Raynaud FI, Valenti M, Eccles S, Te Poele R, Workman P, Aboagye EO, Linardopoulos S. Chan F, et al. Among authors: perumal m. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3147-57. doi: 10.1158/1535-7163.MCT-07-2156. Mol Cancer Ther. 2007. PMID: 18089709

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