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Total synthesis of ciguatoxin and 51-hydroxyCTX3C.
Inoue M, Miyazaki K, Ishihara Y, Tatami A, Ohnuma Y, Kawada Y, Komano K, Yamashita S, Lee N, Hirama M. Inoue M, et al. Among authors: miyazaki k. J Am Chem Soc. 2006 Jul 26;128(29):9352-4. doi: 10.1021/ja063041p. J Am Chem Soc. 2006. PMID: 16848469
First- and second-generation total synthesis of ciguatoxin CTX3C.
Inoue M, Miyazaki K, Uehara H, Maruyama M, Hirama M. Inoue M, et al. Among authors: miyazaki k. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12013-8. doi: 10.1073/pnas.0401684101. Epub 2004 Jun 15. Proc Natl Acad Sci U S A. 2004. PMID: 15199182 Free PMC article.
Synthetic ciguatoxins selectively activate Nav1.8-derived chimeric sodium channels expressed in HEK293 cells.
Yamaoka K, Inoue M, Miyazaki K, Hirama M, Kondo C, Kinoshita E, Miyoshi H, Seyama I. Yamaoka K, et al. Among authors: miyazaki k. J Biol Chem. 2009 Mar 20;284(12):7597-605. doi: 10.1074/jbc.M806481200. Epub 2009 Jan 21. J Biol Chem. 2009. PMID: 19164297 Free PMC article.
The synthetic ciguatoxin CTX3C has been shown to activate tetrodotoxin (TTX)-sensitive sodium channels (Na(v)1.2, Na(v)1.4, and Na(v)1.5) by accelerating activation kinetics and shifting the activation curve toward hyperpolarization (Yamaoka, K., Inoue, M., Miyahara, H., …
The synthetic ciguatoxin CTX3C has been shown to activate tetrodotoxin (TTX)-sensitive sodium channels (Na(v)1.2, Na(v)1.4, and Na(v)1.5) by …
2,671 results