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DNA damage induced in vivo by 7-methoxy-2-nitronaphtho[2,1-b]-furan (R7000) in the lacI gene of Escherichia coli.
Quillardet P, Boscus D, Touati E, Hofnung M. Quillardet P, et al. Among authors: touati e. Mutat Res. 1998 Dec 3;422(2):237-45. doi: 10.1016/s0027-5107(98)00203-6. Mutat Res. 1998. PMID: 9838141
These results show that, guanosine-DNA adducts are the main DNA lesions that block replication induced by R7000 in E. coli and suggests a strong reactivity of the genotoxic species generated in vivo by R7000 with the G nucleotidic targets. From 26 R7000-induced mutations p …
These results show that, guanosine-DNA adducts are the main DNA lesions that block replication induced by R7000 in E. coli and sugges …
66 results