Abraham RT - Search Results

1

The FRB domain of mTOR: NMR solution structure and inhibitor design.

Leone M, Crowell KJ, Chen J, Jung D, Chiang GG, Sareth S, Abraham RT, Pellecchia M. Leone M, et al. Among authors: abraham rt. Biochemistry. 2006 Aug 29;45(34):10294-302. doi: 10.1021/bi060976+. Biochemistry. 2006. PMID: 16922504

2

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase.

Chiang GG, Abraham RT. Chiang GG, et al. Among authors: abraham rt. J Biol Chem. 2005 Jul 8;280(27):25485-90. doi: 10.1074/jbc.M501707200. Epub 2005 May 16. J Biol Chem. 2005. PMID: 15899889 Free article.

3

Targeting the mTOR signaling network in cancer.

Chiang GG, Abraham RT. Chiang GG, et al. Among authors: abraham rt. Trends Mol Med. 2007 Oct;13(10):433-42. doi: 10.1016/j.molmed.2007.08.001. Epub 2007 Oct 1. Trends Mol Med. 2007. PMID: 17905659 Review.

4

Determination of the catalytic activities of mTOR and other members of the phosphoinositide-3-kinase-related kinase family.

Chiang GG, Abraham RT. Chiang GG, et al. Among authors: abraham rt. Methods Mol Biol. 2004;281:125-41. doi: 10.1385/1-59259-811-0:125. Methods Mol Biol. 2004. PMID: 15220525

5

The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures.

Howes AL, Chiang GG, Lang ES, Ho CB, Powis G, Vuori K, Abraham RT. Howes AL, et al. Among authors: abraham rt. Mol Cancer Ther. 2007 Sep;6(9):2505-14. doi: 10.1158/1535-7163.MCT-06-0698. Epub 2007 Aug 31. Mol Cancer Ther. 2007. PMID: 17766839

6

Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival.

Lau E, Chiang GG, Abraham RT, Jiang W. Lau E, et al. Among authors: abraham rt. Mol Biol Cell. 2009 Sep;20(17):3953-64. doi: 10.1091/mbc.e09-01-0022. Epub 2009 Jul 8. Mol Biol Cell. 2009. PMID: 19587119 Free PMC article.

7

Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells.

Edinger AL, Linardic CM, Chiang GG, Thompson CB, Abraham RT. Edinger AL, et al. Among authors: abraham rt. Cancer Res. 2003 Dec 1;63(23):8451-60. Cancer Res. 2003. PMID: 14679009

8

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT. Hudson CC, et al. Among authors: abraham rt. Mol Cell Biol. 2002 Oct;22(20):7004-14. doi: 10.1128/MCB.22.20.7004-7014.2002. Mol Cell Biol. 2002. PMID: 12242281 Free PMC article.

9

Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

Zhang YW, Otterness DM, Chiang GG, Xie W, Liu YC, Mercurio F, Abraham RT. Zhang YW, et al. Among authors: abraham rt. Mol Cell. 2005 Sep 2;19(5):607-18. doi: 10.1016/j.molcel.2005.07.019. Mol Cell. 2005. PMID: 16137618 Free article.

10

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold.

Knight ZA, Chiang GG, Alaimo PJ, Kenski DM, Ho CB, Coan K, Abraham RT, Shokat KM. Knight ZA, et al. Among authors: abraham rt. Bioorg Med Chem. 2004 Sep 1;12(17):4749-59. doi: 10.1016/j.bmc.2004.06.022. Bioorg Med Chem. 2004. PMID: 15358300

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