Watson PS - Search Results

1

2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.

Watson PS, Jiang B, Harrison K, Asakawa N, Welch PK, Covington M, Stowell NC, Wadman EA, Davies P, Solomon KA, Newton RC, Trainor GL, Friedman SM, Decicco CP, Ko SS. Watson PS, et al. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5695-9. doi: 10.1016/j.bmcl.2006.08.012. Epub 2006 Aug 23. Bioorg Med Chem Lett. 2006. PMID: 16931001

2

CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.

Wacker DA, Santella JB 3rd, Gardner DS, Varnes JG, Estrella M, DeLucca GV, Ko SS, Tanabe K, Watson PS, Welch PK, Covington M, Stowell NC, Wadman EA, Davies P, Solomon KA, Newton RC, Trainor GL, Friedman SM, Decicco CP, Duncia JV. Wacker DA, et al. Among authors: watson ps. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1785-9. doi: 10.1016/s0960-894x(02)00206-8. Bioorg Med Chem Lett. 2002. PMID: 12067561

3

Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists.

Varnes JG, Gardner DS, Santella JB 3rd, Duncia JV, Estrella M, Watson PS, Clark CM, Ko SS, Welch P, Covington M, Stowell N, Wadman E, Davies P, Solomon K, Newton RC, Trainor GL, Decicco CP, Wacker DA. Varnes JG, et al. Among authors: watson ps. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1645-9. doi: 10.1016/j.bmcl.2004.01.059. Bioorg Med Chem Lett. 2004. PMID: 15026042

4

From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.

Santella JB 3rd, Gardner DS, Yao W, Shi C, Reddy P, Tebben AJ, DeLucca GV, Wacker DA, Watson PS, Welch PK, Wadman EA, Davies P, Solomon KA, Graden DM, Yeleswaram S, Mandlekar S, Kariv I, Decicco CP, Ko SS, Carter PH, Duncia JV. Santella JB 3rd, et al. Among authors: watson ps. Bioorg Med Chem Lett. 2008 Jan 15;18(2):576-85. doi: 10.1016/j.bmcl.2007.11.067. Epub 2007 Nov 22. Bioorg Med Chem Lett. 2008. PMID: 18096386

5

A diastereoselective synthesis of 2,4-disubstituted piperidines: scaffolds for drug discovery.

Watson PS, Jiang B, Scott B. Watson PS, et al. Org Lett. 2000 Nov 16;2(23):3679-81. doi: 10.1021/ol006589o. Org Lett. 2000. PMID: 11073674

6

Strategy for the enantioselective synthesis of trans-2,4-disubstituted piperidines: application to the CCR3 antagonist IS811.

Kauffman GS, Watson PS, Nugent WA. Kauffman GS, et al. Among authors: watson ps. J Org Chem. 2006 Nov 10;71(23):8975-7. doi: 10.1021/jo0616963. J Org Chem. 2006. PMID: 17081035

7

Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor.

Douglass JG, Patel RI, Yerxa BR, Shaver SR, Watson PS, Bednarski K, Plourde R, Redick CC, Brubaker K, Jones AC, Boyer JL. Douglass JG, et al. Among authors: watson ps. J Med Chem. 2008 Feb 28;51(4):1007-25. doi: 10.1021/jm701348d. Epub 2008 Jan 31. J Med Chem. 2008. PMID: 18232657

8

Adenosine analogues as inhibitors of P2Y12 receptor mediated platelet aggregation.

Douglass JG, deCamp JB, Fulcher EH, Jones W, Mahanty S, Morgan A, Smirnov D, Boyer JL, Watson PS. Douglass JG, et al. Among authors: watson ps. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2167-71. doi: 10.1016/j.bmcl.2008.01.038. Epub 2008 Jan 13. Bioorg Med Chem Lett. 2008. PMID: 18276138

9

Meningococcal-group B (MenB) vaccine series completion and adherence to dosing schedule in the United States: A retrospective analysis by vaccine and payer type.

Packnett E, Irwin DE, Novy P, Watson PS, Whelan J, Moore-Schiltz L, Lucci M, Hogea C. Packnett E, et al. Among authors: watson ps. Vaccine. 2019 Sep 16;37(39):5899-5908. doi: 10.1016/j.vaccine.2019.06.065. Epub 2019 Aug 20. Vaccine. 2019. PMID: 31443990 Free article.

10

Potential benefits of using a multicomponent vaccine for prevention of serogroup B meningococcal disease.

Watson PS, Novy PL, Friedland LR. Watson PS, et al. Int J Infect Dis. 2019 Aug;85:22-27. doi: 10.1016/j.ijid.2019.05.019. Epub 2019 May 16. Int J Infect Dis. 2019. PMID: 31102824 Free article. Review.

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