Jackman AL - Search Results

1

Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography.

Perumal M, Pillai RG, Barthel H, Leyton J, Latigo JR, Forster M, Mitchell F, Jackman AL, Aboagye EO. Perumal M, et al. Among authors: jackman al. Cancer Res. 2006 Sep 1;66(17):8558-64. doi: 10.1158/0008-5472.CAN-06-0898. Cancer Res. 2006. PMID: 16951168

2

Imaging pharmacodynamics of the alpha-folate receptor-targeted thymidylate synthase inhibitor BGC 945.

Pillai RG, Forster M, Perumal M, Mitchell F, Leyton J, Aibgirhio FI, Golovko O, Jackman AL, Aboagye EO. Pillai RG, et al. Among authors: jackman al. Cancer Res. 2008 May 15;68(10):3827-34. doi: 10.1158/0008-5472.CAN-08-0135. Cancer Res. 2008. PMID: 18483267 Free PMC article.

3

BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors.

Gibbs DD, Theti DS, Wood N, Green M, Raynaud F, Valenti M, Forster MD, Mitchell F, Bavetsias V, Henderson E, Jackman AL. Gibbs DD, et al. Among authors: jackman al. Cancer Res. 2005 Dec 15;65(24):11721-8. doi: 10.1158/0008-5472.CAN-05-2034. Cancer Res. 2005. PMID: 16357184

4

A phase I trial of ZD9331, a water-soluble, nonpolyglutamatable, thymidylate synthase inhibitor.

Plummer R, Rees C, Hughes A, Beale P, Highley M, Trigo J, Gokul S, Judson I, Calvert H, Jackman A, Mitchell F, Smith R, Douglass E. Plummer R, et al. Clin Cancer Res. 2003 Apr;9(4):1313-22. Clin Cancer Res. 2003. PMID: 12684399 Clinical Trial.

5

Patterns of elevation of plasma 2'-deoxyuridine, a surrogate marker of thymidylate synthase (TS) inhibition, after administration of two different schedules of 5-fluorouracil and the specific TS inhibitors raltitrexed (Tomudex) and ZD9331.

Ford HE, Mitchell F, Cunningham D, Farrugia DC, Hill ME, Rees C, Calvert AH, Judson IR, Jackman AL. Ford HE, et al. Among authors: jackman al. Clin Cancer Res. 2002 Jan;8(1):103-9. Clin Cancer Res. 2002. PMID: 11801545 Clinical Trial.

6

Phase I trial of ZD9331, a nonpolyglutamatable thymidylate synthase inhibitor, given as a 5-day continuous infusion to patients with refractory solid malignancies.

Rees C, Beale P, Trigo JM, Mitchell F, Jackman A, Smith R, Douglass E, Judson I. Rees C, et al. Clin Cancer Res. 2003 Jun;9(6):2049-55. Clin Cancer Res. 2003. PMID: 12796367 Clinical Trial.

7

Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.

van der Wilt CL, Backus HH, Smid K, Comijn L, Veerman G, Wouters D, Voorn DA, Priest DG, Bunni MA, Mitchell F, Jackman AL, Jansen G, Peters GJ. van der Wilt CL, et al. Among authors: jackman al. Cancer Res. 2001 May 1;61(9):3675-81. Cancer Res. 2001. PMID: 11325838

8

Flow cytometric method for determining folate receptor expression on ovarian carcinoma cells.

Forster MD, Ormerod MG, Agarwal R, Kaye SB, Jackman AL. Forster MD, et al. Among authors: jackman al. Cytometry A. 2007 Nov;71(11):945-50. doi: 10.1002/cyto.a.20456. Cytometry A. 2007. PMID: 17712798 Free article.

9

The renal effects of the water-soluble, non-folylpolyglutamate synthetase-dependent thymidylate synthase inhibitor ZD9331 in mice.

Walton MI, Mitchell F, Aherne GW, Medlow CJ, Boyle FT, Jackman AL. Walton MI, et al. Among authors: jackman al. Br J Cancer. 1998 Dec;78(11):1457-63. doi: 10.1038/bjc.1998.707. Br J Cancer. 1998. PMID: 9836478 Free PMC article.

10

A phase I pharmacokinetic and pharmacodynamic study of BGC9331 and carboplatin in relapsed gynaecological malignancies.

Benepal T, Jackman A, Pyle L, Bate S, Hardcastle A, Aherne W, Mitchell F, Simmons L, Ruddle R, Raynaud F, Gore M. Benepal T, et al. Br J Cancer. 2005 Oct 17;93(8):868-75. doi: 10.1038/sj.bjc.6602811. Br J Cancer. 2005. PMID: 16222320 Free PMC article. Clinical Trial.

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