Hughes RH - Search Results

1

PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.

Bray PG, Mungthin M, Hastings IM, Biagini GA, Saidu DK, Lakshmanan V, Johnson DJ, Hughes RH, Stocks PA, O'Neill PM, Fidock DA, Warhurst DC, Ward SA. Bray PG, et al. Among authors: hughes rh. Mol Microbiol. 2006 Oct;62(1):238-51. doi: 10.1111/j.1365-2958.2006.05368.x. Epub 2006 Aug 31. Mol Microbiol. 2006. PMID: 16956382 Free PMC article.

2

Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial drugs.

Biagini GA, Pasini EM, Hughes R, De Koning HP, Vial HJ, O'Neill PM, Ward SA, Bray PG. Biagini GA, et al. Blood. 2004 Nov 15;104(10):3372-7. doi: 10.1182/blood-2004-03-1084. Epub 2004 Jun 17. Blood. 2004. PMID: 15205262 Free article.

3

The pH of the Plasmodium falciparum digestive vacuole: holy grail or dead-end trail?

Spiller DG, Bray PG, Hughes RH, Ward SA, White MR. Spiller DG, et al. Among authors: hughes rh. Trends Parasitol. 2002 Oct;18(10):441-4. doi: 10.1016/s1471-4922(02)02365-6. Trends Parasitol. 2002. PMID: 12377594 Review.

4

Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.

O'Neill PM, Mukhtar A, Stocks PA, Randle LE, Hindley S, Ward SA, Storr RC, Bickley JF, O'Neil IA, Maggs JL, Hughes RH, Winstanley PA, Bray PG, Park BK. O'Neill PM, et al. Among authors: hughes rh. J Med Chem. 2003 Nov 6;46(23):4933-45. doi: 10.1021/jm030796n. J Med Chem. 2003. PMID: 14584944

5

A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.

Lakshmanan V, Bray PG, Verdier-Pinard D, Johnson DJ, Horrocks P, Muhle RA, Alakpa GE, Hughes RH, Ward SA, Krogstad DJ, Sidhu AB, Fidock DA. Lakshmanan V, et al. Among authors: hughes rh. EMBO J. 2005 Jul 6;24(13):2294-305. doi: 10.1038/sj.emboj.7600681. Epub 2005 Jun 9. EMBO J. 2005. PMID: 15944738 Free PMC article.

6

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

Stocks PA, Bray PG, Barton VE, Al-Helal M, Jones M, Araujo NC, Gibbons P, Ward SA, Hughes RH, Biagini GA, Davies J, Amewu R, Mercer AE, Ellis G, O'Neill PM. Stocks PA, et al. Among authors: hughes rh. Angew Chem Int Ed Engl. 2007;46(33):6278-83. doi: 10.1002/anie.200604697. Angew Chem Int Ed Engl. 2007. PMID: 17640025 No abstract available.

7

Plasmodium falciparum: sacrificing membrane to grow crystals?

Hempelmann E, Motta C, Hughes R, Ward SA, Bray PG. Hempelmann E, et al. Trends Parasitol. 2003 Jan;19(1):23-6. doi: 10.1016/s1471-4922(02)00011-9. Trends Parasitol. 2003. PMID: 12488222 No abstract available.

8

Accumulation of the antimalarial microtubule inhibitors trifluralin and vinblastine by Plasmodium falciparum.

Naughton JA, Hughes R, Bray P, Bell A. Naughton JA, et al. Biochem Pharmacol. 2008 Apr 15;75(8):1580-7. doi: 10.1016/j.bcp.2008.01.002. Epub 2008 Jan 16. Biochem Pharmacol. 2008. PMID: 18291349

9

Preventive antibody products are immunizations.

Hughes RH, Choudhury S. Hughes RH, et al. Vaccine. 2023 Nov 22;41(48):7041-7043. doi: 10.1016/j.vaccine.2023.10.046. Epub 2023 Oct 24. Vaccine. 2023. PMID: 37884414 No abstract available.

10

Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control.

Ulloa Severino FP, Lawal OO, Sakers K, Wang S, Kim N, Friedman AD, Johnson SA, Sriworarat C, Hughes RH, Soderling SH, Kim IH, Yin HH, Eroglu C. Ulloa Severino FP, et al. Among authors: hughes rh. Nat Commun. 2023 Sep 8;14(1):5522. doi: 10.1038/s41467-023-41078-z. Nat Commun. 2023. PMID: 37684234 Free PMC article.

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