Beugels I - Search Results

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Plant sterol or stanol esters retard lesion formation in LDL receptor-deficient mice independent of changes in serum plant sterols.

Plat J, Beugels I, Gijbels MJ, de Winther MP, Mensink RP. Plat J, et al. Among authors: beugels i. J Lipid Res. 2006 Dec;47(12):2762-71. doi: 10.1194/jlr.M600346-JLR200. Epub 2006 Sep 6. J Lipid Res. 2006. PMID: 16957178 Free article.

Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone.

Minnaard-Huiban M, Emmen JM, Roumen L, Beugels IP, Cohuet GM, van Essen H, Ruijters E, Pieterse K, Hilbers PA, Ottenheijm HC, Plate R, de Gooyer ME, Smits JF, Hermans JJ. Minnaard-Huiban M, et al. Among authors: beugels ip. Endocrinology. 2008 Jan;149(1):28-31. doi: 10.1210/en.2007-0584. Epub 2007 Sep 20. Endocrinology. 2008. PMID: 17884944

Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).

Roumen L, Peeters JW, Emmen JM, Beugels IP, Custers EM, de Gooyer M, Plate R, Pieterse K, Hilbers PA, Smits JF, Vekemans JA, Leysen D, Ottenheijm HC, Janssen HM, Hermans JJ. Roumen L, et al. Among authors: beugels ip. J Med Chem. 2010 Feb 25;53(4):1712-25. doi: 10.1021/jm901356d. J Med Chem. 2010. PMID: 20121113

Application of a ligand-based theoretical approach to derive conversion paths and ligand conformations in CYP11B2-mediated aldosterone formation.

Roumen L, Van Hoof B, Pieterse K, Hilbers PA, Custers EM, Plate R, De Gooyer M, Beugels IP, Emmen JM, Leysen D, Smits JF, Ottenheijm HC, Hermans JJ. Roumen L, et al. Among authors: beugels ip. J Comput Chem. 2011 Aug;32(11):2441-8. doi: 10.1002/jcc.21827. Epub 2011 May 19. J Comput Chem. 2011. PMID: 21598279

Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics.

Roumen L, Sanders MP, Pieterse K, Hilbers PA, Plate R, Custers E, de Gooyer M, Smits JF, Beugels I, Emmen J, Ottenheijm HC, Leysen D, Hermans JJ. Roumen L, et al. Among authors: beugels i. J Comput Aided Mol Des. 2007 Aug;21(8):455-71. doi: 10.1007/s10822-007-9128-9. Epub 2007 Jul 24. J Comput Aided Mol Des. 2007. PMID: 17646925 Free PMC article.

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