Nelson SD - Search Results

1

Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase.

Wen B, Lampe JN, Roberts AG, Atkins WM, David Rodrigues A, Nelson SD. Wen B, et al. Among authors: nelson sd. Arch Biochem Biophys. 2006 Oct 1;454(1):42-54. doi: 10.1016/j.abb.2006.08.003. Epub 2006 Aug 22. Arch Biochem Biophys. 2006. PMID: 16959210 Free PMC article.

2

Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study.

Cameron MD, Wen B, Allen KE, Roberts AG, Schuman JT, Campbell AP, Kunze KL, Nelson SD. Cameron MD, et al. Among authors: nelson sd. Biochemistry. 2005 Nov 1;44(43):14143-51. doi: 10.1021/bi051689t. Biochemistry. 2005. PMID: 16245930

3

Probing the CYP3A4 active site by cysteine scanning mutagenesis and photoaffinity labeling.

Wen B, Doneanu CE, Lampe JN, Roberts AG, Atkins WM, Nelson SD. Wen B, et al. Among authors: nelson sd. Arch Biochem Biophys. 2005 Dec 15;444(2):100-11. doi: 10.1016/j.abb.2005.09.010. Epub 2005 Oct 21. Arch Biochem Biophys. 2005. PMID: 16289363

4

Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site.

Cameron MD, Wen B, Roberts AG, Atkins WM, Campbell AP, Nelson SD. Cameron MD, et al. Among authors: nelson sd. Chem Res Toxicol. 2007 Oct;20(10):1434-41. doi: 10.1021/tx7000702. Epub 2007 Sep 26. Chem Res Toxicol. 2007. PMID: 17894464

5

Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b(5).

Zhao C, Gao Q, Roberts AG, Shaffer SA, Doneanu CE, Xue S, Goodlett DR, Nelson SD, Atkins WM. Zhao C, et al. Among authors: nelson sd. Biochemistry. 2012 Nov 27;51(47):9488-500. doi: 10.1021/bi301069r. Epub 2012 Nov 14. Biochemistry. 2012. PMID: 23150942 Free PMC article.

6

Fluorescent photoaffinity labeling of cytochrome P450 3A4 by lapachenole: identification of modification sites by mass spectrometry.

Wen B, Doneanu CE, Gartner CA, Roberts AG, Atkins WM, Nelson SD. Wen B, et al. Among authors: nelson sd. Biochemistry. 2005 Feb 15;44(6):1833-45. doi: 10.1021/bi048228c. Biochemistry. 2005. PMID: 15697209

7

Glutathione S-transferase catalyzes the isomerization of (R)-2-hydroxymenthofuran to mintlactones.

Khojasteh-Bakht SC, Nelson SD, Atkins WM. Khojasteh-Bakht SC, et al. Among authors: nelson sd. Arch Biochem Biophys. 1999 Oct 1;370(1):59-65. doi: 10.1006/abbi.1999.1361. Arch Biochem Biophys. 1999. PMID: 10496977

8

Multiple-ligand binding in CYP2A6: probing mechanisms of cytochrome P450 cooperativity by assessing substrate dynamics.

Harrelson JP, Atkins WM, Nelson SD. Harrelson JP, et al. Among authors: nelson sd. Biochemistry. 2008 Mar 4;47(9):2978-88. doi: 10.1021/bi702020y. Epub 2008 Feb 5. Biochemistry. 2008. PMID: 18247580

9

The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4.

Roberts AG, Yang J, Halpert JR, Nelson SD, Thummel KT, Atkins WM. Roberts AG, et al. Among authors: nelson sd. Biochemistry. 2011 Dec 20;50(50):10804-18. doi: 10.1021/bi200924t. Epub 2011 Nov 22. Biochemistry. 2011. PMID: 21992114 Free PMC article.

10

Photochromic agents as tools for protein structure study: lapachenole is a photoaffinity ligand of cytochrome P450 3A4.

Gartner CA, Wen B, Wan J, Becker RS, Jones G 2nd, Gygi SP, Nelson SD. Gartner CA, et al. Among authors: nelson sd. Biochemistry. 2005 Feb 15;44(6):1846-55. doi: 10.1021/bi049231z. Biochemistry. 2005. PMID: 15697210

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