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Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2.
Klebba JE, Roy N, Bernard SM, Grabow S, Hoffman MA, Miao H, Tamiya J, Wang J, Berry C, Esparza-Oros A, Lin R, Liu Y, Pariollaud M, Parker H, Mochalkin I, Rana S, Snead AN, Walton EJ, Wyrick TE, Aitichson E, Bedke K, Brannon JC, Chick JM, Hee K, Horning BD, Ismail M, Lamb KN, Lin W, Metzger J, Pastuszka MK, Pollock J, Sigler JJ, Tomaschko M, Tran E, Kinsella TM, Molina-Arcas M, Simon GM, Weinstein DS, Downward J, Patricelli MP. Klebba JE, et al. Among authors: lin r. bioRxiv [Preprint]. 2024 Dec 20:2024.12.17.629001. doi: 10.1101/2024.12.17.629001. bioRxiv. 2024. PMID: 39763752 Free PMC article. Preprint.
Basic Considerations for the Consistency Evaluation Based on ICH E17 Guideline.
Long M, Wu H, Liu X, Li P, Lin R, Zhao Z, Kou X, Zhu C, Ji C, Zhang W, Zhang K, Yu B, Wang Y, Zhang H, Jia F, Hou Y. Long M, et al. Among authors: lin r. Ther Innov Regul Sci. 2025 Jan 6. doi: 10.1007/s43441-024-00737-z. Online ahead of print. Ther Innov Regul Sci. 2025. PMID: 39762631
Uniform single-crystal mesoporous metal-organic frameworks.
Lv Z, Lin R, Yang Y, Lan K, Hung CT, Zhang P, Wang J, Zhou W, Zhao Z, Wang Z, Zou J, Wang T, Zhao T, Xu Y, Chao D, Tan W, Yan B, Li Q, Zhao D, Li X. Lv Z, et al. Among authors: lin r. Nat Chem. 2025 Jan 6. doi: 10.1038/s41557-024-01693-9. Online ahead of print. Nat Chem. 2025. PMID: 39762625
6,903 results