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Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-kappaB (nf-kappaB) activation and nf-kappaB-regulated gene expression.
Ichikawa H, Nair MS, Takada Y, Sheeja DB, Kumar MA, Oommen OV, Aggarwal BB. Ichikawa H, et al. Among authors: nair ms. Clin Cancer Res. 2006 Oct 1;12(19):5910-8. doi: 10.1158/1078-0432.CCR-06-0916. Clin Cancer Res. 2006. PMID: 17021000
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
Kunnumakkara AB, Ichikawa H, Anand P, Mohankumar CJ, Hema PS, Nair MS, Aggarwal BB. Kunnumakkara AB, et al. Among authors: nair ms. Mol Cancer Ther. 2008 Oct;7(10):3306-17. doi: 10.1158/1535-7163.MCT-08-0432. Mol Cancer Ther. 2008. Retraction in: Mol Cancer Ther. 2018 Sep;17(9):2074. doi: 10.1158/1535-7163.MCT-18-0871 PMID: 18852134 Retracted.
Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents.
Gupta SC, Kannappan R, Kim J, Rahman GM, Francis SK, Raveendran R, Nair MS, Das J, Aggarwal BB. Gupta SC, et al. Among authors: nair ms. Mol Pharmacol. 2011 Nov;80(5):769-81. doi: 10.1124/mol.111.073122. Epub 2011 Jul 27. Mol Pharmacol. 2011. PMID: 21795584 Free PMC article.
Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.
Gupta SC, Prasad S, Reuter S, Kannappan R, Yadav VR, Ravindran J, Hema PS, Chaturvedi MM, Nair M, Aggarwal BB. Gupta SC, et al. J Biol Chem. 2010 Nov 12;285(46):35406-17. doi: 10.1074/jbc.M110.161984. Epub 2010 Sep 9. J Biol Chem. 2010. PMID: 20829362 Free PMC article.
Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway.
Prasad S, Yadav VR, Sundaram C, Reuter S, Hema PS, Nair MS, Chaturvedi MM, Aggarwal BB. Prasad S, et al. Among authors: nair ms. J Biol Chem. 2010 Aug 27;285(35):26987-27000. doi: 10.1074/jbc.M110.121061. Epub 2010 Jun 23. J Biol Chem. 2010. Retraction in: J Biol Chem. 2016 Aug 5;291(32):16921. doi: 10.1074/jbc.A110.121061 PMID: 20576605 Free PMC article. Retracted.
Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway.
Gupta SC, Francis SK, Nair MS, Mo YY, Aggarwal BB. Gupta SC, et al. Among authors: nair ms. J Biol Chem. 2013 Nov 8;288(45):32343-32356. doi: 10.1074/jbc.M113.455188. Epub 2013 Sep 27. J Biol Chem. 2013. PMID: 24078627 Free PMC article.
Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.
Gupta SC, Reuter S, Phromnoi K, Park B, Hema PS, Nair M, Aggarwal BB. Gupta SC, et al. J Biol Chem. 2011 Jan 14;286(2):1134-46. doi: 10.1074/jbc.M110.191379. Epub 2010 Nov 15. J Biol Chem. 2011. Retraction in: J Biol Chem. 2016 Aug 5;291(32):16925. doi: 10.1074/jbc.A110.191379 PMID: 21078664 Free PMC article. Retracted.
210 results