Varga E - Search Results

1

New paradigms and tools in drug design for pain and addiction.

Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. Hruby VJ, et al. Among authors: varga e. AAPS J. 2006 Jul 14;8(3):E450-60. doi: 10.1208/aapsj080353. AAPS J. 2006. PMID: 17025262 Free PMC article. Review.

2

Direct observation of G-protein binding to the human delta-opioid receptor using plasmon-waveguide resonance spectroscopy.

Alves ID, Salamon Z, Varga E, Yamamura HI, Tollin G, Hruby VJ. Alves ID, et al. Among authors: varga e. J Biol Chem. 2003 Dec 5;278(49):48890-7. doi: 10.1074/jbc.M306866200. Epub 2003 Sep 30. J Biol Chem. 2003. PMID: 14522991 Free article.

3

Selectivity, cooperativity, and reciprocity in the interactions between the delta-opioid receptor, its ligands, and G-proteins.

Alves ID, Ciano KA, Boguslavski V, Varga E, Salamon Z, Yamamura HI, Hruby VJ, Tollin G. Alves ID, et al. Among authors: varga e. J Biol Chem. 2004 Oct 22;279(43):44673-82. doi: 10.1074/jbc.M404713200. Epub 2004 Aug 17. J Biol Chem. 2004. PMID: 15317820 Free article.

4

Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling.

Georgieva T, Devanathan S, Stropova D, Park CK, Salamon Z, Tollin G, Hruby VJ, Roeske WR, Yamamura HI, Varga E. Georgieva T, et al. Among authors: varga e. Eur J Pharmacol. 2008 Feb 26;581(1-2):19-29. doi: 10.1016/j.ejphar.2007.11.053. Epub 2007 Nov 28. Eur J Pharmacol. 2008. PMID: 18162180 Free PMC article.

5

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.

Vardanyan R, Kumirov VK, Nichol GS, Davis P, Liktor-Busa E, Rankin D, Varga E, Vanderah T, Porreca F, Lai J, Hruby VJ. Vardanyan R, et al. Among authors: varga e. Bioorg Med Chem. 2011 Oct 15;19(20):6135-42. doi: 10.1016/j.bmc.2011.08.027. Epub 2011 Aug 24. Bioorg Med Chem. 2011. PMID: 21925887 Free PMC article.

6

Agonist-specific down-regulation of the human delta-opioid receptor.

Okura T, Varga EV, Hosohata Y, Navratilova E, Cowell SM, Rice K, Nagase H, Hruby VJ, Roeske WR, Yamamura HI. Okura T, et al. Among authors: varga ev. Eur J Pharmacol. 2003 Jan 10;459(1):9-16. doi: 10.1016/s0014-2999(02)02823-6. Eur J Pharmacol. 2003. PMID: 12505529

7

(2S,3R) beta-methyl-2',6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-L-Tic-OH] is a potent, selective delta-opioid receptor antagonist in mouse brain.

Hosohata K, Varga EV, Alfaro-Lopez J, Tang X, Vanderah TW, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. Hosohata K, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):683-8. doi: 10.1124/jpet.102.042929. J Pharmacol Exp Ther. 2003. PMID: 12538822

8

Molecular mechanisms of excitatory signaling upon chronic opioid agonist treatment.

Varga EV, Yamamura HI, Rubenzik MK, Stropova D, Navratilova E, Roeske WR. Varga EV, et al. Life Sci. 2003 Dec 5;74(2-3):299-311. doi: 10.1016/j.lfs.2003.09.017. Life Sci. 2003. PMID: 14607258 Review.

9

Morphine promotes phosphorylation of the human delta-opioid receptor at serine 363.

Navratilova E, Eaton MC, Stropova D, Varga EV, Vanderah TW, Roeske WR, Yamamura HI. Navratilova E, et al. Among authors: varga ev. Eur J Pharmacol. 2005 Sep 20;519(3):212-4. doi: 10.1016/j.ejphar.2005.07.024. Eur J Pharmacol. 2005. PMID: 16135360

10

Chronic morphine-mediated adenylyl cyclase superactivation is attenuated by the Raf-1 inhibitor, GW5074.

Yue X, Varga EV, Stropova D, Vanderah TW, Yamamura HI, Roeske WR. Yue X, et al. Eur J Pharmacol. 2006 Jul 1;540(1-3):57-9. doi: 10.1016/j.ejphar.2006.04.033. Epub 2006 May 3. Eur J Pharmacol. 2006. PMID: 16750187

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