Newell DR - Search Results

1

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.

Hardcastle IR, Ahmed SU, Atkins H, Farnie G, Golding BT, Griffin RJ, Guyenne S, Hutton C, Källblad P, Kemp SJ, Kitching MS, Newell DR, Norbedo S, Northen JS, Reid RJ, Saravanan K, Willems HM, Lunec J. Hardcastle IR, et al. Among authors: newell dr. J Med Chem. 2006 Oct 19;49(21):6209-21. doi: 10.1021/jm0601194. J Med Chem. 2006. PMID: 17034127

2

In vivo and ex vivo magnetic resonance spectroscopy as applied to pharmacokinetic studies with anticancer agents: a review.

Newell DR, Maxwell RJ, Golding BT. Newell DR, et al. NMR Biomed. 1992 Sep-Oct;5(5):273-8. doi: 10.1002/nbm.1940050514. NMR Biomed. 1992. PMID: 1449968 Review.

3

Novel potent inhibitors of the DNA repair enzyme poly(ADP-ribose)polymerase (PARP).

Griffin RJ, Pemberton LC, Rhodes D, Bleasdale C, Bowman K, Calvert AH, Curtin NJ, Durkacz BW, Newell DR, Porteous JK, et al. Griffin RJ, et al. Among authors: newell dr. Anticancer Drug Des. 1995 Sep;10(6):507-14. Anticancer Drug Des. 1995. PMID: 7575991 No abstract available.

4

The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy.

Griffin RJ, Curtin NJ, Newell DR, Golding BT, Durkacz BW, Calvert AH. Griffin RJ, et al. Among authors: newell dr. Biochimie. 1995;77(6):408-22. doi: 10.1016/0300-9084(96)88154-5. Biochimie. 1995. PMID: 7578423 Review.

5

Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines).

Arris CE, Bleasdale C, Calvert AH, Curtin NJ, Dalby C, Golding BT, Griffin RJ, Lunn JM, Major GN, Newell DR. Arris CE, et al. Among authors: newell dr. Anticancer Drug Des. 1994 Oct;9(5):401-8. Anticancer Drug Des. 1994. PMID: 7945724 No abstract available.

6

The relationship between intrinsic thymidylate synthase expression and sensitivity to THYMITAQ in human leukaemia and colorectal carcinoma cell lines.

Estlin EJ, Balmanno K, Calvert AH, Hall AG, Lunec J, Newell DR, Pearson AD, Taylor GA. Estlin EJ, et al. Among authors: newell dr. Br J Cancer. 1997;76(12):1579-85. doi: 10.1038/bjc.1997.600. Br J Cancer. 1997. PMID: 9413945 Free PMC article.

7

Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

Griffin RJ, Srinivasan S, Bowman K, Calvert AH, Curtin NJ, Newell DR, Pemberton LC, Golding BT. Griffin RJ, et al. Among authors: newell dr. J Med Chem. 1998 Dec 17;41(26):5247-56. doi: 10.1021/jm980273t. J Med Chem. 1998. PMID: 9857092

8

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding.

Curtin NJ, Bowman KJ, Turner RN, Huang B, Loughlin PJ, Calvert AH, Golding BT, Griffin RJ, Newell DR. Curtin NJ, et al. Among authors: newell dr. Br J Cancer. 1999 Aug;80(11):1738-46. doi: 10.1038/sj.bjc.6690591. Br J Cancer. 1999. PMID: 10468290 Free PMC article.

9

Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.

Barnes MJ, Estlin EJ, Taylor GA, Aherne GW, Hardcastle A, McGuire JJ, Calvete JA, Lunec J, Pearson AD, Newell DR. Barnes MJ, et al. Among authors: newell dr. Clin Cancer Res. 1999 Sep;5(9):2548-58. Clin Cancer Res. 1999. PMID: 10499632

10

Resistance-modifying agents. Part 7: 2,6-disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of alpha1-acid glycoprotein (AGP).

Barlow HC, Bowman KJ, Curtin NJ, Calvert AH, Golding BT, Huang B, Loughlin PJ, Newell DR, Smith PG, Griffin RJ. Barlow HC, et al. Among authors: newell dr. Bioorg Med Chem Lett. 2000 Mar 20;10(6):585-9. doi: 10.1016/s0960-894x(00)00053-6. Bioorg Med Chem Lett. 2000. PMID: 10741559

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