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Mature human Langerhans cells derived from CD34+ hematopoietic progenitors stimulate greater cytolytic T lymphocyte activity in the absence of bioactive IL-12p70, by either single peptide presentation or cross-priming, than do dermal-interstitial or monocyte-derived dendritic cells.
Ratzinger G, Baggers J, de Cos MA, Yuan J, Dao T, Reagan JL, Münz C, Heller G, Young JW. Ratzinger G, et al. Among authors: yuan j. J Immunol. 2004 Aug 15;173(4):2780-91. doi: 10.4049/jimmunol.173.4.2780. J Immunol. 2004. PMID: 15294997
Safety and immunogenicity of tyrosinase DNA vaccines in patients with melanoma.
Wolchok JD, Yuan J, Houghton AN, Gallardo HF, Rasalan TS, Wang J, Zhang Y, Ranganathan R, Chapman PB, Krown SE, Livingston PO, Heywood M, Riviere I, Panageas KS, Terzulli SL, Perales MA. Wolchok JD, et al. Among authors: yuan j. Mol Ther. 2007 Nov;15(11):2044-50. doi: 10.1038/sj.mt.6300290. Epub 2007 Aug 28. Mol Ther. 2007. PMID: 17726460 Free article. Clinical Trial.
Phase I/II study of GM-CSF DNA as an adjuvant for a multipeptide cancer vaccine in patients with advanced melanoma.
Perales MA, Yuan J, Powel S, Gallardo HF, Rasalan TS, Gonzalez C, Manukian G, Wang J, Zhang Y, Chapman PB, Krown SE, Livingston PO, Ejadi S, Panageas KS, Engelhorn ME, Terzulli SL, Houghton AN, Wolchok JD. Perales MA, et al. Among authors: yuan j. Mol Ther. 2008 Dec;16(12):2022-9. doi: 10.1038/mt.2008.196. Epub 2008 Sep 16. Mol Ther. 2008. PMID: 18797450 Free PMC article. Clinical Trial.
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit.
Yuan J, Gnjatic S, Li H, Powel S, Gallardo HF, Ritter E, Ku GY, Jungbluth AA, Segal NH, Rasalan TS, Manukian G, Xu Y, Roman RA, Terzulli SL, Heywood M, Pogoriler E, Ritter G, Old LJ, Allison JP, Wolchok JD. Yuan J, et al. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20410-5. doi: 10.1073/pnas.0810114105. Epub 2008 Dec 12. Proc Natl Acad Sci U S A. 2008. PMID: 19074257 Free PMC article. Clinical Trial.
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