Wang Y - Search Results

1

Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity.

Jones PJ, Wang Y, Smith MD, Hargus NJ, Eidam HS, White HS, Kapur J, Brown ML, Patel MK. Jones PJ, et al. Among authors: wang y. J Pharmacol Exp Ther. 2007 Feb;320(2):828-36. doi: 10.1124/jpet.106.111542. Epub 2006 Nov 7. J Pharmacol Exp Ther. 2007. PMID: 17090703

2

Modulation of sodium channel inactivation gating by a novel lactam: implications for seizure suppression in chronic limbic epilepsy.

Jones PJ, Merrick EC, Batts TW, Hargus NJ, Wang Y, Stables JP, Bertram EH, Brown ML, Patel MK. Jones PJ, et al. Among authors: wang y. J Pharmacol Exp Ther. 2009 Jan;328(1):201-12. doi: 10.1124/jpet.108.144709. Epub 2008 Oct 24. J Pharmacol Exp Ther. 2009. PMID: 18952887 Free PMC article.

3

Ligand-based design and synthesis of novel sodium channel blockers from a combined phenytoin-lidocaine pharmacophore.

Wang Y, Jones PJ, Batts TW, Landry V, Patel MK, Brown ML. Wang Y, et al. Bioorg Med Chem. 2009 Oct 1;17(19):7064-72. doi: 10.1016/j.bmc.2008.10.031. Epub 2008 Oct 17. Bioorg Med Chem. 2009. PMID: 19346132 Free PMC article.

4

Probing the mechanism of bioactivation of MPTP type analogs by monoamine oxidase B: structure-activity studies on substituted 4-phenoxy-, 4-phenyl-, and 4-thiophenoxy-1-cyclopropyl-1,2,3,6-tetrahydropyridines.

Rimoldi JM, Wang YX, Nimkar SK, Kuttab SH, Anderson AH, Burch H, Castagnoli N Jr. Rimoldi JM, et al. Among authors: wang yx. Chem Res Toxicol. 1995 Jul-Aug;8(5):703-10. doi: 10.1021/tx00047a010. Chem Res Toxicol. 1995. PMID: 7548753

5

Studies on the monoamine oxidase (MAO)-catalyzed oxidation of phenyl-substituted 1-methyl-4-phenoxy-1,2,3,6-tetrahydropyridine derivatives: factors contributing to MAO-A and MAO-B selectivity.

Wang YX, Castagnoli N Jr. Wang YX, et al. J Med Chem. 1995 May 26;38(11):1904-10. doi: 10.1021/jm00011a010. J Med Chem. 1995. PMID: 7783122

6

Potential latent nitrogen mustard derivatives designed to target monoamine oxidase rich cells.

Wang YX, Castagnoli N Jr. Wang YX, et al. Bioorg Med Chem. 1997 Jul;5(7):1321-5. doi: 10.1016/s0968-0896(97)00056-4. Bioorg Med Chem. 1997. PMID: 9377092

7

Biotransformation of the MPTP analog trans-1-methyl-4-[4-dimethylaminophenylethenyl]-1,2,3,6-tetra- hydropyridine to a fluorescent pyridinium metabolite by intact neuroblastoma cells.

Song X, Ehrich M, Flaherty D, Wang YX, Castagnoli N. Song X, et al. Among authors: wang yx. Toxicol Appl Pharmacol. 1996 Apr;137(2):163-72. doi: 10.1006/taap.1996.0069. Toxicol Appl Pharmacol. 1996. PMID: 8661341

8

Synthesis and selective monoamine oxidase B-inhibiting properties of 1-methyl-1,2,3,6-tetrahydropyrid-4-yl carbamate derivatives: potential prodrugs of (R)- and (S)-nordeprenyl.

Flaherty P, Castagnoli K, Wang YX, Castagnoli N Jr. Flaherty P, et al. Among authors: wang yx. J Med Chem. 1996 Nov 22;39(24):4756-61. doi: 10.1021/jm960477e. J Med Chem. 1996. PMID: 8941389

9

1-Methyl-3-pyrrolines and 2-methylisoindolines: new classes of cyclic tertiary amine monoamine oxidase B substrates.

Wang YX, Mabic S, Castagnoli N Jr. Wang YX, et al. Bioorg Med Chem. 1998 Feb;6(2):143-9. doi: 10.1016/s0968-0896(97)10020-7. Bioorg Med Chem. 1998. PMID: 9547937

10

Synthesis and monoamine oxidase B catalyzed oxidation of C-4 heteroaromatic substituted 1,2,3,6-tetrahydropyridine derivatives.

Nimkar SK, Anderson AH, Rimoldi JM, Stanton M, Castagnoli KP, Mabic S, Wang YX, Castagnoli N Jr. Nimkar SK, et al. Among authors: wang yx. Chem Res Toxicol. 1996 Sep;9(6):1013-22. doi: 10.1021/tx960063o. Chem Res Toxicol. 1996. PMID: 8870990

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