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Enriching productive mutational paths accelerates enzyme evolution.
Patsch D, Schwander T, Voss M, Schaub D, Hüppi S, Eichenberger M, Stockinger P, Schelbert L, Giger S, Peccati F, Jiménez-Osés G, Mutný M, Krause A, Bornscheuer UT, Hilvert D, Buller RM. Patsch D, et al. Among authors: buller rm. Nat Chem Biol. 2024 Dec;20(12):1662-1669. doi: 10.1038/s41589-024-01712-3. Epub 2024 Sep 11. Nat Chem Biol. 2024. PMID: 39261644 Free PMC article.
Highly conserved influenza T cell epitopes induce broadly protective immunity.
Eickhoff CS, Terry FE, Peng L, Meza KA, Sakala IG, Van Aartsen D, Moise L, Martin WD, Schriewer J, Buller RM, De Groot AS, Hoft DF. Eickhoff CS, et al. Among authors: buller rm. Vaccine. 2019 Aug 23;37(36):5371-5381. doi: 10.1016/j.vaccine.2019.07.033. Epub 2019 Jul 19. Vaccine. 2019. PMID: 31331771 Free PMC article.
Directed evolution of carbon-hydrogen bond activating enzymes.
Frey R, Hayashi T, Buller RM. Frey R, et al. Among authors: buller rm. Curr Opin Biotechnol. 2019 Dec;60:29-38. doi: 10.1016/j.copbio.2018.12.004. Epub 2018 Dec 21. Curr Opin Biotechnol. 2019. PMID: 30583278 Review.
Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents.
Ananthula HK, Parker S, Touchette E, Buller RM, Patel G, Kalman D, Salzer JS, Gallardo-Romero N, Olson V, Damon IK, Moir-Savitz T, Sallans L, Werner MH, Sherwin CM, Desai PB. Ananthula HK, et al. Among authors: buller rm. BMC Pharmacol Toxicol. 2018 Dec 4;19(1):80. doi: 10.1186/s40360-018-0270-x. BMC Pharmacol Toxicol. 2018. PMID: 30514402 Free PMC article.
152 results