Kubo K - Search Results

1

A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.

Ohno H, Kubo K, Murooka H, Kobayashi Y, Nishitoba T, Shibuya M, Yoneda T, Isoe T. Ohno H, et al. Among authors: kubo k. Mol Cancer Ther. 2006 Nov;5(11):2634-43. doi: 10.1158/1535-7163.MCT-05-0313. Mol Cancer Ther. 2006. PMID: 17121910

2

KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth.

Nakamura K, Yamamoto A, Kamishohara M, Takahashi K, Taguchi E, Miura T, Kubo K, Shibuya M, Isoe T. Nakamura K, et al. Among authors: kubo k. Mol Cancer Ther. 2004 Dec;3(12):1639-49. Mol Cancer Ther. 2004. PMID: 15634658

3

The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model.

Ohno H, Uemura Y, Murooka H, Takanashi H, Tokieda T, Ohzeki Y, Kubo K, Serizawa I. Ohno H, et al. Among authors: kubo k. Eur J Immunol. 2008 Jan;38(1):283-91. doi: 10.1002/eji.200737199. Eur J Immunol. 2008. PMID: 18085662 Free article.

4

The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis.

Uemura Y, Ohno H, Ohzeki Y, Takanashi H, Murooka H, Kubo K, Serizawa I. Uemura Y, et al. Among authors: kubo k. J Neuroimmunol. 2008 Mar;195(1-2):73-80. doi: 10.1016/j.jneuroim.2008.01.015. Epub 2008 Apr 2. J Neuroimmunol. 2008. PMID: 18378004

5

Synthesis and structure-activity relationship for new series of 4-phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase.

Kubo K, Ohyama S, Shimizu T, Takami A, Murooka H, Nishitoba T, Kato S, Yagi M, Kobayashi Y, Iinuma N, Isoe T, Nakamura K, Iijima H, Osawa T, Izawa T. Kubo K, et al. Bioorg Med Chem. 2003 Nov 17;11(23):5117-33. doi: 10.1016/j.bmc.2003.08.020. Bioorg Med Chem. 2003. PMID: 14604675

6

Orally active anti-proliferation agents: novel diphenylamine derivatives as FGF-R2 autophosphorylation inhibitors.

Shimizu T, Fujiwara Y, Osawa T, Sakai T, Kubo K, Kubo K, Nishitoba T, Kimura K, Senga T, Murooka H, Iwai A, Fukushima K, Yoshino T, Miwa A. Shimizu T, et al. Among authors: kubo k. Bioorg Med Chem Lett. 2004 Feb 23;14(4):875-9. doi: 10.1016/j.bmcl.2003.12.019. Bioorg Med Chem Lett. 2004. PMID: 15012985

7

Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.

Kubo K, Shimizu T, Ohyama S, Murooka H, Iwai A, Nakamura K, Hasegawa K, Kobayashi Y, Takahashi N, Takahashi K, Kato S, Izawa T, Isoe T. Kubo K, et al. J Med Chem. 2005 Mar 10;48(5):1359-66. doi: 10.1021/jm030427r. J Med Chem. 2005. PMID: 15743179

8

KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties.

Nakamura K, Taguchi E, Miura T, Yamamoto A, Takahashi K, Bichat F, Guilbaud N, Hasegawa K, Kubo K, Fujiwara Y, Suzuki R, Kubo K, Shibuya M, Isae T. Nakamura K, et al. Among authors: kubo k. Cancer Res. 2006 Sep 15;66(18):9134-42. doi: 10.1158/0008-5472.CAN-05-4290. Cancer Res. 2006. PMID: 16982756

9

Antineoplastic effect of a single oral dose of the novel Flt3 inhibitor KRN383 on xenografted human leukemic cells harboring Flt3-activating mutations.

Nishiyama U, Yoshino T, Ozai M, Yoshioka R, Fujisawa M, Ogasawara Y, Kitahori M, Yoshioka E, Kubo K, Komeno Y, Kurokawa M, Ogawa S, Chiba S, Osawa T, Kuwaki T, Hirai H, Miwa A. Nishiyama U, et al. Among authors: kubo k. Leuk Res. 2006 Dec;30(12):1541-6. doi: 10.1016/j.leukres.2006.02.028. Epub 2006 Apr 17. Leuk Res. 2006. PMID: 16603240

10

Identification of potent and selective inhibitors of PDGF receptor autophosphorylation.

Furuta T, Sakai T, Senga T, Osawa T, Kubo K, Shimizu T, Suzuki R, Yoshino T, Endo M, Miwa A. Furuta T, et al. Among authors: kubo k. J Med Chem. 2006 Apr 6;49(7):2186-92. doi: 10.1021/jm0506423. J Med Chem. 2006. PMID: 16570914

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