Toxicology study of repeat intracerebral administration of a measles virus derivative producing carcinoembryonic antigen in rhesus macaques in support of a phase I/II clinical trial for patients with recurrent gliomas.
Myers R, Harvey M, Kaufmann TJ, Greiner SM, Krempski JW, Raffel C, Shelton SE, Soeffker D, Zollman P, Federspiel MJ, Blanco M, Galanis E.
Myers R, et al.
Hum Gene Ther. 2008 Jul;19(7):690-8. doi: 10.1089/hum.2008.035.
Hum Gene Ther. 2008.
PMID: 18576918
Free PMC article.
We have previously demonstrated that oncolytic measles virus strains derived from the Edmonston vaccine lineage have significant antitumor activity against gliomas [Phuong, L.K., Allen, C., Peng, K.W., Giannini, C., Greiner, S., Teneyck, C.J., Mishra, P.K., Macura, …
We have previously demonstrated that oncolytic measles virus strains derived from the Edmonston vaccine lineage have significant antitumor a …