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The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway.
Lehnes K, Winder AD, Alfonso C, Kasid N, Simoneaux M, Summe H, Morgan E, Iann MC, Duncan J, Eagan M, Tavaluc R, Evans CH Jr, Russell R, Wang A, Hu F, Stoica A. Lehnes K, et al. Among authors: iann mc. Endocrinology. 2007 Mar;148(3):1171-80. doi: 10.1210/en.2006-1179. Epub 2006 Nov 30. Endocrinology. 2007. PMID: 17138652