Damha MJ - Search Results

1

Characterization of antisense oligonucleotides comprising 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA): specificity, potency, and duration of activity.

Ferrari N, Bergeron D, Tedeschi AL, Mangos MM, Paquet L, Renzi PM, Damha MJ. Ferrari N, et al. Among authors: damha mj. Ann N Y Acad Sci. 2006 Oct;1082:91-102. doi: 10.1196/annals.1348.032. Ann N Y Acad Sci. 2006. PMID: 17145930

2

Properties of arabinonucleic acids (ANA & 20'F-ANA): implications for the design of antisense therapeutics that invoke RNase H cleavage of RNA.

Damha MJ, Noronha AM, Wilds CJ, Trempe JF, Denisov A, Pon RT, Gehring K. Damha MJ, et al. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):429-40. doi: 10.1081/NCN-100002317. Nucleosides Nucleotides Nucleic Acids. 2001. PMID: 11563058

3

Solution structure of an arabinonucleic acid (ANA)/RNA duplex in a chimeric hairpin: comparison with 2'-fluoro-ANA/RNA and DNA/RNA hybrids.

Denisov AY, Noronha AM, Wilds CJ, Trempe JF, Pon RT, Gehring K, Damha MJ. Denisov AY, et al. Among authors: damha mj. Nucleic Acids Res. 2001 Nov 1;29(21):4284-93. doi: 10.1093/nar/29.21.4284. Nucleic Acids Res. 2001. PMID: 11691916 Free PMC article.

4

Potent gene-specific inhibitory properties of mixed-backbone antisense oligonucleotides comprised of 2'-deoxy-2'-fluoro-D-arabinose and 2'-deoxyribose nucleotides.

Lok CN, Viazovkina E, Min KL, Nagy E, Wilds CJ, Damha MJ, Parniak MA. Lok CN, et al. Among authors: damha mj. Biochemistry. 2002 Mar 12;41(10):3457-67. doi: 10.1021/bi0115075. Biochemistry. 2002. PMID: 11876654

5

Flexible and frozen sugar-modified nucleic acids--modulation of biological activity through furanose ring dynamics in the antisense strand.

Mangos MM, Damha MJ. Mangos MM, et al. Among authors: damha mj. Curr Top Med Chem. 2002 Oct;2(10):1147-71. doi: 10.2174/1568026023393110. Curr Top Med Chem. 2002. PMID: 12173972 Review.

6

Oligonucleotides comprised of alternating 2'-deoxy-2'-fluoro-beta-D-arabinonucleosides and D-2'-deoxyribonucleosides (2'F-ANA/DNA 'altimers') induce efficient RNA cleavage mediated by RNase H.

Min KL, Viazovkina E, Galarneau A, Parniak MA, Damha MJ. Min KL, et al. Among authors: damha mj. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2651-4. doi: 10.1016/s0960-894x(02)00439-0. Bioorg Med Chem Lett. 2002. PMID: 12182880

7

Efficient RNase H-directed cleavage of RNA promoted by antisense DNA or 2'F-ANA constructs containing acyclic nucleotide inserts.

Mangos MM, Min KL, Viazovkina E, Galarneau A, Elzagheid MI, Parniak MA, Damha MJ. Mangos MM, et al. Among authors: damha mj. J Am Chem Soc. 2003 Jan 22;125(3):654-61. doi: 10.1021/ja025557o. J Am Chem Soc. 2003. PMID: 12526664

8

Synthesis and physicochemical properties of 2'-deoxy-2',2''-difluoro-beta-D-ribofuranosyl and 2'-deoxy-2',2''-difluoro-alpha-D-ribofuranosyl oligonucleotides.

Viazovkina E, Mangos MM, Damha MJ. Viazovkina E, et al. Among authors: damha mj. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1251-4. doi: 10.1081/NCN-120022848. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565392

9

Branchpoint sugar stereochemistry determines the hydrolytic susceptibility of branched RNA fragments by the yeast debranching enzyme (YDBR).

Carriero S, Mangos MM, Agha KA, Noronha AM, Damha MJ. Carriero S, et al. Among authors: damha mj. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1599-602. doi: 10.1081/NCN-120023043. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565475

10

Assay for evaluating ribonuclease H-mediated degradation of RNA-antisense oligonucleotide duplexes.

Galarneau A, Min KL, Mangos MM, Damha MJ. Galarneau A, et al. Among authors: damha mj. Methods Mol Biol. 2005;288:65-80. doi: 10.1385/1-59259-823-4:065. Methods Mol Biol. 2005. PMID: 15333898

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