Brandt P - Search Results

1

Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor.

Koehler K, Gordon S, Brandt P, Carlsson B, Bäcksbro-Saeidi A, Apelqvist T, Agback P, Grover GJ, Nelson W, Grynfarb M, Färnegårdh M, Rehnmark S, Malm J. Koehler K, et al. Among authors: brandt p. J Med Chem. 2006 Nov 16;49(23):6635-7. doi: 10.1021/jm060521i. J Med Chem. 2006. PMID: 17154490

2

Thyroid receptor ligands. Part 7: Indirect antagonists of the thyroid hormone receptor with improved affinity.

Malm J, Gordon S, Brandt P, Carlsson B, Agback P, Bäckbro Saeidi A, Sandberg J. Malm J, et al. Among authors: brandt p. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2018-21. doi: 10.1016/j.bmcl.2007.01.009. Epub 2007 Jan 13. Bioorg Med Chem Lett. 2007. PMID: 17254783

3

Deconstruction of non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1 for exploration of the optimization landscape of fragments.

Brandt P, Geitmann M, Danielson UH. Brandt P, et al. J Med Chem. 2011 Feb 10;54(3):709-18. doi: 10.1021/jm101052g. Epub 2011 Jan 5. J Med Chem. 2011. PMID: 21207958

4

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB).

De Rosa M, Lu L, Zamaratski E, Szałaj N, Cao S, Wadensten H, Lenhammar L, Gising J, Roos AK, Huseby DL, Larsson R, Andrén PE, Hughes D, Brandt P, Mowbray SL, Karlén A. De Rosa M, et al. Among authors: brandt p. Bioorg Med Chem. 2017 Feb 1;25(3):897-911. doi: 10.1016/j.bmc.2016.12.003. Epub 2016 Dec 7. Bioorg Med Chem. 2017. PMID: 28038943 Free article.

5

Identification of a novel scaffold for allosteric inhibition of wild type and drug resistant HIV-1 reverse transcriptase by fragment library screening.

Geitmann M, Elinder M, Seeger C, Brandt P, de Esch IJ, Danielson UH. Geitmann M, et al. Among authors: brandt p. J Med Chem. 2011 Feb 10;54(3):699-708. doi: 10.1021/jm1010513. Epub 2011 Jan 5. J Med Chem. 2011. PMID: 21207961

6

Small kinase assay panels can provide a measure of selectivity.

Brandt P, Jensen AJ, Nilsson J. Brandt P, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5861-3. doi: 10.1016/j.bmcl.2009.08.083. Epub 2009 Aug 27. Bioorg Med Chem Lett. 2009. PMID: 19748779

7

Pan-NS3 protease inhibitors of hepatitis C virus based on an R³-elongated pyrazinone scaffold.

Belfrage AK, Abdurakhmanov E, Åkerblom E, Brandt P, Alogheli H, Neyts J, Danielson UH, Sandström A. Belfrage AK, et al. Among authors: brandt p. Eur J Med Chem. 2018 Mar 25;148:453-464. doi: 10.1016/j.ejmech.2018.02.032. Epub 2018 Feb 13. Eur J Med Chem. 2018. PMID: 29477077

8

Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase.

Szałaj N, Lu L, Benediktsdottir A, Zamaratski E, Cao S, Olanders G, Hedgecock C, Karlén A, Erdélyi M, Hughes D, Mowbray SL, Brandt P. Szałaj N, et al. Among authors: brandt p. Eur J Med Chem. 2018 Sep 5;157:1346-1360. doi: 10.1016/j.ejmech.2018.08.086. Epub 2018 Aug 30. Eur J Med Chem. 2018. PMID: 30196059

9

Discovery of pyrazinone based compounds that potently inhibit the drug-resistant enzyme variant R155K of the hepatitis C virus NS3 protease.

Belfrage AK, Abdurakhmanov E, Kerblom E, Brandt P, Oshalim A, Gising J, Skogh A, Neyts J, Danielson UH, Sandström A. Belfrage AK, et al. Among authors: brandt p. Bioorg Med Chem. 2016 Jun 15;24(12):2603-20. doi: 10.1016/j.bmc.2016.03.066. Epub 2016 Apr 8. Bioorg Med Chem. 2016. PMID: 27160057

10

Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs.

Olanders G, Brandt P, Sköld C, Karlén A. Olanders G, et al. Among authors: brandt p. Bioorg Med Chem. 2021 Nov 1;49:116399. doi: 10.1016/j.bmc.2021.116399. Epub 2021 Sep 11. Bioorg Med Chem. 2021. PMID: 34601455 Free article.

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