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Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid.
Rollema H, Chambers LK, Coe JW, Glowa J, Hurst RS, Lebel LA, Lu Y, Mansbach RS, Mather RJ, Rovetti CC, Sands SB, Schaeffer E, Schulz DW, Tingley FD 3rd, Williams KE. Rollema H, et al. Among authors: lu y. Neuropharmacology. 2007 Mar;52(3):985-94. doi: 10.1016/j.neuropharm.2006.10.016. Epub 2006 Dec 8. Neuropharmacology. 2007. PMID: 17157884
Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation.
Coe JW, Brooks PR, Vetelino MG, Wirtz MC, Arnold EP, Huang J, Sands SB, Davis TI, Lebel LA, Fox CB, Shrikhande A, Heym JH, Schaeffer E, Rollema H, Lu Y, Mansbach RS, Chambers LK, Rovetti CC, Schulz DW, Tingley FD 3rd, O'Neill BT. Coe JW, et al. Among authors: lu y. J Med Chem. 2005 May 19;48(10):3474-7. doi: 10.1021/jm050069n. J Med Chem. 2005. PMID: 15887955
Pharmacological characterization of 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ-opioid receptors.
Grimwood S, Lu Y, Schmidt AW, Vanase-Frawley MA, Sawant-Basak A, Miller E, McLean S, Freeman J, Wong S, McLaughlin JP, Verhoest PR. Grimwood S, et al. Among authors: lu y. J Pharmacol Exp Ther. 2011 Nov;339(2):555-66. doi: 10.1124/jpet.111.185108. Epub 2011 Aug 5. J Pharmacol Exp Ther. 2011. PMID: 21821697
Biomarkers.
Blew CO, Duggan MR, Joynes CM, Gomez GT, Tian Q, Pilling LC, Chen J, Rooney MR, Schlosser P, Herman AB, Tsitsipatis D, Fornage M, Gottesman RF, Palta P, Lu Y, Ballantyne CM, Griswold ME, Coresh J, Walker KA. Blew CO, et al. Among authors: lu y. Alzheimers Dement. 2024 Dec;20 Suppl 2:e086953. doi: 10.1002/alz.086953. Alzheimers Dement. 2024. PMID: 39786285
Biomarkers.
Zhang W, Lü Y. Zhang W, et al. Among authors: lu y. Alzheimers Dement. 2024 Dec;20 Suppl 2:e086101. doi: 10.1002/alz.086101. Alzheimers Dement. 2024. PMID: 39786211
Public Health.
Zhang W, Ascher SB, Dolui S, Nasrallah IM, Lu Y, Neitzel J, Toledo E, Glodzik L, Hughes TM, Berry JD, Ma Y. Zhang W, et al. Among authors: lu y. Alzheimers Dement. 2024 Dec;20 Suppl 7:e087991. doi: 10.1002/alz.087991. Alzheimers Dement. 2024. PMID: 39784725 Clinical Trial.
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