Breitenbach JM - Search Results

1

Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir.

Eriksson U, Hilfinger JM, Kim JS, Mitchell S, Kijek P, Borysko KZ, Breitenbach JM, Drach JC, Kashemirov BA, McKenna CE. Eriksson U, et al. Among authors: breitenbach jm. Bioorg Med Chem Lett. 2007 Feb 1;17(3):583-6. doi: 10.1016/j.bmcl.2006.11.012. Epub 2006 Nov 10. Bioorg Med Chem Lett. 2007. PMID: 17161946 Free PMC article.

2

Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir.

Peterson LW, Kim JS, Kijek P, Mitchell S, Hilfinger J, Breitenbach J, Borysko K, Drach JC, Kashemirov BA, McKenna CE. Peterson LW, et al. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4045-9. doi: 10.1016/j.bmcl.2011.04.126. Epub 2011 May 3. Bioorg Med Chem Lett. 2011. PMID: 21641218 Free PMC article.

3

Serine peptide phosphoester prodrugs of cyclic cidofovir: synthesis, transport, and antiviral activity.

Eriksson U, Peterson LW, Kashemirov BA, Hilfinger JM, Drach JC, Borysko KZ, Breitenbach JM, Kim JS, Mitchell S, Kijek P, McKenna CE. Eriksson U, et al. Among authors: breitenbach jm. Mol Pharm. 2008 Jul-Aug;5(4):598-609. doi: 10.1021/mp8000099. Epub 2008 May 16. Mol Pharm. 2008. PMID: 18481868 Free PMC article.

4

Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.

Zakharova VM, Serpi M, Krylov IS, Peterson LW, Breitenbach JM, Borysko KZ, Drach JC, Collins M, Hilfinger JM, Kashemirov BA, McKenna CE. Zakharova VM, et al. Among authors: breitenbach jm. J Med Chem. 2011 Aug 25;54(16):5680-93. doi: 10.1021/jm2001426. Epub 2011 Aug 3. J Med Chem. 2011. PMID: 21812420 Free PMC article.

5

Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.

Zhou S, Breitenbach JM, Borysko KZ, Drach JC, Kern ER, Gullen E, Cheng YC, Zemlicka J. Zhou S, et al. Among authors: breitenbach jm. J Med Chem. 2004 Jan 29;47(3):566-75. doi: 10.1021/jm030316s. J Med Chem. 2004. PMID: 14736238

6

Design and synthesis of vidarabine prodrugs as antiviral agents.

Shen W, Kim JS, Kish PE, Zhang J, Mitchell S, Gentry BG, Breitenbach JM, Drach JC, Hilfinger J. Shen W, et al. Among authors: breitenbach jm. Bioorg Med Chem Lett. 2009 Feb 1;19(3):792-6. doi: 10.1016/j.bmcl.2008.12.031. Epub 2008 Dec 10. Bioorg Med Chem Lett. 2009. PMID: 19097789 Free PMC article.

7

Deoxy sugar analogues of triciribine: correlation of antiviral and antiproliferative activity with intracellular phosphorylation.

Porcari AR, Ptak RG, Borysko KZ, Breitenbach JM, Vittori S, Wotring LL, Drach JC, Townsend LB. Porcari AR, et al. Among authors: breitenbach jm. J Med Chem. 2000 Jun 15;43(12):2438-48. doi: 10.1021/jm990205m. J Med Chem. 2000. PMID: 10882371

8

6-N-Acyltriciribine analogues: structure-activity relationship between acyl carbon chain length and activity against HIV-1.

Porcari AR, Ptak RG, Borysko KZ, Breitenbach JM, Drach JC, Townsend LB. Porcari AR, et al. Among authors: breitenbach jm. J Med Chem. 2000 Jun 15;43(12):2457-63. doi: 10.1021/jm990236h. J Med Chem. 2000. PMID: 10882373

9

Synthesis and antiviral activity of 2-substituted analogs of triciribine.

Porcari AR, Ptak RG, Borysko KZ, Breitenbach JM, Drach JC, Townsend LB. Porcari AR, et al. Among authors: breitenbach jm. Nucleosides Nucleotides Nucleic Acids. 2003 Dec;22(12):2171-93. doi: 10.1081/ncn-120026873. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14714765

10

Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo.

Lorenzi PL, Landowski CP, Song X, Borysko KZ, Breitenbach JM, Kim JS, Hilfinger JM, Townsend LB, Drach JC, Amidon GL. Lorenzi PL, et al. Among authors: breitenbach jm. J Pharmacol Exp Ther. 2005 Aug;314(2):883-90. doi: 10.1124/jpet.104.082412. Epub 2005 May 18. J Pharmacol Exp Ther. 2005. PMID: 15901797

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