Bredesen DE - Search Results

1

Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP.

Saganich MJ, Schroeder BE, Galvan V, Bredesen DE, Koo EH, Heinemann SF. Saganich MJ, et al. Among authors: bredesen de. J Neurosci. 2006 Dec 27;26(52):13428-36. doi: 10.1523/JNEUROSCI.4180-06.2006. J Neurosci. 2006. PMID: 17192425 Free PMC article.

2

Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein.

Park SA, Shaked GM, Bredesen DE, Koo EH. Park SA, et al. Among authors: bredesen de. Biochem Biophys Res Commun. 2009 Oct 16;388(2):450-5. doi: 10.1016/j.bbrc.2009.08.042. Epub 2009 Aug 11. Biochem Biophys Res Commun. 2009. PMID: 19679105 Free PMC article.

3

Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity.

Lu DC, Soriano S, Bredesen DE, Koo EH. Lu DC, et al. Among authors: bredesen de. J Neurochem. 2003 Nov;87(3):733-41. doi: 10.1046/j.1471-4159.2003.02059.x. J Neurochem. 2003. PMID: 14535955 Free article.

4

Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624).

Shaked GM, Kummer MP, Lu DC, Galvan V, Bredesen DE, Koo EH. Shaked GM, et al. Among authors: bredesen de. FASEB J. 2006 Jun;20(8):1254-6. doi: 10.1096/fj.05-5032fje. Epub 2006 Apr 24. FASEB J. 2006. PMID: 16636103 Free PMC article.

5

Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.

Nguyen TV, Galvan V, Huang W, Banwait S, Tang H, Zhang J, Bredesen DE. Nguyen TV, et al. Among authors: bredesen de. J Neurochem. 2008 Feb;104(4):1065-80. doi: 10.1111/j.1471-4159.2007.05031.x. Epub 2007 Nov 6. J Neurochem. 2008. PMID: 17986220 Free PMC article.

6

C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease.

Banwait S, Galvan V, Zhang J, Gorostiza OF, Ataie M, Huang W, Crippen D, Koo EH, Bredesen DE. Banwait S, et al. Among authors: bredesen de. J Alzheimers Dis. 2008 Feb;13(1):1-16. doi: 10.3233/jad-2008-13101. J Alzheimers Dis. 2008. PMID: 18334752 Free PMC article.

7

Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience.

Zhang J, Gorostiza OF, Tang H, Bredesen DE, Galvan V. Zhang J, et al. Among authors: bredesen de. Behav Brain Res. 2010 Jan 20;206(2):202-7. doi: 10.1016/j.bbr.2009.09.013. Epub 2009 Sep 12. Behav Brain Res. 2010. PMID: 19751769 Free PMC article.

8

Importance of the caspase cleavage site in amyloid-β protein precursor.

Bredesen DE, John V, Galvan V. Bredesen DE, et al. J Alzheimers Dis. 2010;22(1):57-63. doi: 10.3233/JAD-2010-100537. J Alzheimers Dis. 2010. PMID: 20847422 Free PMC article. Review.

9

Caspase cleavage of members of the amyloid precursor family of proteins.

Galvan V, Chen S, Lu D, Logvinova A, Goldsmith P, Koo EH, Bredesen DE. Galvan V, et al. Among authors: bredesen de. J Neurochem. 2002 Jul;82(2):283-94. doi: 10.1046/j.1471-4159.2002.00970.x. J Neurochem. 2002. PMID: 12124429 Free article.

10

Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes.

Lu DC, Shaked GM, Masliah E, Bredesen DE, Koo EH. Lu DC, et al. Among authors: bredesen de. Ann Neurol. 2003 Dec;54(6):781-9. doi: 10.1002/ana.10761. Ann Neurol. 2003. PMID: 14681887

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