Kochansky CJ - Search Results

1

Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs.

Beconi MG, Reed JR, Teffera Y, Xia YQ, Kochansky CJ, Liu DQ, Xu S, Elmore CS, Ciccotto S, Hora DF, Stearns RA, Vincent SH. Beconi MG, et al. Among authors: kochansky cj. Drug Metab Dispos. 2007 Apr;35(4):525-32. doi: 10.1124/dmd.106.013110. Epub 2007 Jan 12. Drug Metab Dispos. 2007. PMID: 17220241

2

Identification and metabolism of a novel dihydrohydroxy-S-glutathionyl conjugate of a peroxisome proliferator-activated receptor agonist, MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], in rats.

Reddy VB, Doss GA, Creighton M, Kochansky CJ, Vincent SH, Franklin RB, Karanam BV. Reddy VB, et al. Among authors: kochansky cj. Drug Metab Dispos. 2004 Oct;32(10):1154-61. doi: 10.1124/dmd.104.000240. Epub 2004 Jun 30. Drug Metab Dispos. 2004. PMID: 15229171

3

Differences in the pharmacokinetics of peroxisome proliferator-activated receptor agonists in genetically obese Zucker and sprague-dawley rats: implications of decreased glucuronidation in obese Zucker rats.

Kim MS, Wang S, Shen Z, Kochansky CJ, Strauss JR, Franklin RB, Vincent SH. Kim MS, et al. Among authors: kochansky cj. Drug Metab Dispos. 2004 Sep;32(9):909-14. Drug Metab Dispos. 2004. PMID: 15319330

4

Species differences in the elimination of a peroxisome proliferator-activated receptor agonist highlighted by oxidative metabolism of its acyl glucuronide.

Kochansky CJ, Xia YQ, Wang S, Cato B, Creighton M, Vincent SH, Franklin RB, Reed JR. Kochansky CJ, et al. Drug Metab Dispos. 2005 Dec;33(12):1894-904. doi: 10.1124/dmd.105.004010. Epub 2005 Sep 23. Drug Metab Dispos. 2005. PMID: 16183782

5

Absorption, metabolism, and excretion of [14C]MK-0767 (2-methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in humans.

Kochansky CJ, Rippley RK, Yan KX, Song H, Wallace MA, Dean D, Jones AN, Lasseter K, Schwartz J, Vincent SH, Franklin RB, Wagner J. Kochansky CJ, et al. Drug Metab Dispos. 2006 Sep;34(9):1457-61. doi: 10.1124/dmd.106.010231. Epub 2006 Jun 13. Drug Metab Dispos. 2006. PMID: 16772365 Clinical Trial.

6

Metabolism and pharmacokinetics of a dipeptidyl peptidase IV inhibitor in rats, dogs, and monkeys with selective carbamoyl glucuronidation of the primary amine in dogs.

Beconi MG, Mao A, Liu DQ, Kochansky C, Pereira T, Raab C, Pearson P, Lee Chiu SH. Beconi MG, et al. Drug Metab Dispos. 2003 Oct;31(10):1269-77. doi: 10.1124/dmd.31.10.1269. Drug Metab Dispos. 2003. PMID: 12975337

7

Differences in the metabolism and pharmacokinetics of two structurally similar PPAR agonists in dogs: involvement of taurine conjugation.

Kim MS, Shen Z, Kochansky C, Lynn K, Wang S, Wang Z, Hora D, Brunner J, Franklin RB, Vincent SH. Kim MS, et al. Xenobiotica. 2004 Jul;34(7):665-74. doi: 10.1080/00498250412331285445. Xenobiotica. 2004. PMID: 15672754

8

Simultaneous determination of MK-0767 and seven metabolites in rat urine using liquid chromatography/tandem mass spectrometry.

Shen Z, Kochansky C, Bakhtiar R, Franklin RB, Vincent SH. Shen Z, et al. Rapid Commun Mass Spectrom. 2004;18(18):2113-20. doi: 10.1002/rcm.1597. Rapid Commun Mass Spectrom. 2004. PMID: 15317046

9

The role of P-glycoprotein in the bioactivation of raloxifene.

Chang JH, Kochansky CJ, Shou M. Chang JH, et al. Among authors: kochansky cj. Drug Metab Dispos. 2006 Dec;34(12):2073-8. doi: 10.1124/dmd.106.012179. Epub 2006 Sep 7. Drug Metab Dispos. 2006. PMID: 16959878

10

Impact of pH on plasma protein binding in equilibrium dialysis.

Kochansky CJ, McMasters DR, Lu P, Koeplinger KA, Kerr HH, Shou M, Korzekwa KR. Kochansky CJ, et al. Mol Pharm. 2008 May-Jun;5(3):438-48. doi: 10.1021/mp800004s. Epub 2008 Mar 18. Mol Pharm. 2008. PMID: 18345638

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