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Antimycobacterial Activity and Mechanism of Action of NAS-91.
Gratraud P, Surolia N, Besra GS, Surolia A, Kremer L. Gratraud P, et al. Antimicrob Agents Chemother. 2008 Mar;52(3):1162-6. doi: 10.1128/AAC.00968-07. Epub 2007 Dec 17. Antimicrob Agents Chemother. 2008. PMID: 18086849 Free PMC article.
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Yu M, Kumar TR, Nkrumah LJ, Coppi A, Retzlaff S, Li CD, Kelly BJ, Moura PA, Lakshmanan V, Freundlich JS, Valderramos JC, Vilcheze C, Siedner M, Tsai JH, Falkard B, Sidhu AB, Purcell LA, Gratraud P, Kremer L, Waters AP, Schiehser G, Jacobus DP, Janse CJ, Ager A, Jacobs WR Jr, Sacchettini JC, Heussler V, Sinnis P, Fidock DA. Yu M, et al. Among authors: gratraud p. Cell Host Microbe. 2008 Dec 11;4(6):567-78. doi: 10.1016/j.chom.2008.11.001. Cell Host Microbe. 2008. PMID: 19064257 Free PMC article.