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Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers.
Hamill TG, Krause S, Ryan C, Bonnefous C, Govek S, Seiders TJ, Cosford ND, Roppe J, Kamenecka T, Patel S, Gibson RE, Sanabria S, Riffel K, Eng W, King C, Yang X, Green MD, O'Malley SS, Hargreaves R, Burns HD. Hamill TG, et al. Synapse. 2005 Jun 15;56(4):205-16. doi: 10.1002/syn.20147. Synapse. 2005. PMID: 15803497
A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation.
Kreisl WC, Jenko KJ, Hines CS, Lyoo CH, Corona W, Morse CL, Zoghbi SS, Hyde T, Kleinman JE, Pike VW, McMahon FJ, Innis RB; Biomarkers Consortium PET Radioligand Project Team. Kreisl WC, et al. J Cereb Blood Flow Metab. 2013 Jan;33(1):53-8. doi: 10.1038/jcbfm.2012.131. Epub 2012 Sep 12. J Cereb Blood Flow Metab. 2013. PMID: 22968319 Free PMC article.
Visualization and quantification of neurokinin-1 (NK1) receptors in the human brain.
Hietala J, Nyman MJ, Eskola O, Laakso A, Grönroos T, Oikonen V, Bergman J, Haaparanta M, Forsback S, Marjamäki P, Lehikoinen P, Goldberg M, Burns D, Hamill T, Eng WS, Coimbra A, Hargreaves R, Solin O. Hietala J, et al. Mol Imaging Biol. 2005 Jul-Aug;7(4):262-72. doi: 10.1007/s11307-005-7001-6. Mol Imaging Biol. 2005. PMID: 16155744
186 results