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Page 1
Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity.
D'Amico DC, Aya T, Human J, Fotsch C, Chen JJ, Biswas K, Riahi B, Norman MH, Willoughby CA, Hungate R, Reider PJ, Biddlecome G, Lester-Zeiner D, Staden CV, Johnson E, Kamassah A, Arik L, Wang J, Viswanadhan VN, Groneberg RD, Zhan J, Suzuki H, Toro A, Mareska DA, Clarke DE, Harvey DM, Burgess LE, Laird ER, Askew B, Ng G. D'Amico DC, et al. Among authors: laird er. J Med Chem. 2007 Feb 22;50(4):607-10. doi: 10.1021/jm061224g. Epub 2007 Jan 23. J Med Chem. 2007. PMID: 17243660
Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors.
Letavic MA, Axt MZ, Barberia JT, Carty TJ, Danley DE, Geoghegan KF, Halim NS, Hoth LR, Kamath AV, Laird ER, Lopresti-Morrow LL, McClure KF, Mitchell PG, Natarajan V, Noe MC, Pandit J, Reeves L, Schulte GK, Snow SL, Sweeney FJ, Tan DH, Yu CH. Letavic MA, et al. Among authors: laird er. Bioorg Med Chem Lett. 2002 May 20;12(10):1387-90. doi: 10.1016/s0960-894x(02)00183-x. Bioorg Med Chem Lett. 2002. PMID: 11992783
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.
Blagg JA, Noe MC, Wolf-Gouveia LA, Reiter LA, Laird ER, Chang SP, Danley DE, Downs JT, Elliott NC, Eskra JD, Griffiths RJ, Hardink JR, Haugeto AI, Jones CS, Liras JL, Lopresti-Morrow LL, Mitchell PG, Pandit J, Robinson RP, Subramanyam C, Vaughn-Bowser ML, Yocum SA. Blagg JA, et al. Among authors: laird er. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1807-10. doi: 10.1016/j.bmcl.2005.02.038. Bioorg Med Chem Lett. 2005. PMID: 15780611
Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase.
McClure KF, Abramov YA, Laird ER, Barberia JT, Cai W, Carty TJ, Cortina SR, Danley DE, Dipesa AJ, Donahue KM, Dombroski MA, Elliott NC, Gabel CA, Han S, Hynes TR, Lemotte PK, Mansour MN, Marr ES, Letavic MA, Pandit J, Ripin DB, Sweeney FJ, Tan D, Tao Y. McClure KF, et al. Among authors: laird er. J Med Chem. 2005 Sep 8;48(18):5728-37. doi: 10.1021/jm050346q. J Med Chem. 2005. PMID: 16134941
Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development.
McClure KF, Letavic MA, Kalgutkar AS, Gabel CA, Audoly L, Barberia JT, Braganza JF, Carter D, Carty TJ, Cortina SR, Dombroski MA, Donahue KM, Elliott NC, Gibbons CP, Jordan CK, Kuperman AV, Labasi JM, Laliberte RE, McCoy JM, Naiman BM, Nelson KL, Nguyen HT, Peese KM, Sweeney FJ, Taylor TJ, Trebino CE, Abramov YA, Laird ER, Volberg WA, Zhou J, Bach J, Lombardo F. McClure KF, et al. Among authors: laird er. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4339-44. doi: 10.1016/j.bmcl.2006.05.056. Epub 2006 Jun 12. Bioorg Med Chem Lett. 2006. PMID: 16759861
Potent, selective pyrimidinetrione-based inhibitors of MMP-13.
Reiter LA, Freeman-Cook KD, Jones CS, Martinelli GJ, Antipas AS, Berliner MA, Datta K, Downs JT, Eskra JD, Forman MD, Greer EM, Guzman R, Hardink JR, Janat F, Keene NF, Laird ER, Liras JL, Lopresti-Morrow LL, Mitchell PG, Pandit J, Robertson D, Sperger D, Vaughn-Bowser ML, Waller DM, Yocum SA. Reiter LA, et al. Among authors: laird er. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5822-6. doi: 10.1016/j.bmcl.2006.08.066. Epub 2006 Aug 30. Bioorg Med Chem Lett. 2006. PMID: 16942871
41 results