Alhamadsheh MM - Search Results

1

Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis.

Alhamadsheh MM, Palaniappan N, Daschouduri S, Reynolds KA. Alhamadsheh MM, et al. J Am Chem Soc. 2007 Feb 21;129(7):1910-1. doi: 10.1021/ja068818t. Epub 2007 Jan 27. J Am Chem Soc. 2007. PMID: 17256943 Free PMC article.

2

cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme.

Palaniappan N, Alhamadsheh MM, Reynolds KA. Palaniappan N, et al. Among authors: alhamadsheh mm. J Am Chem Soc. 2008 Sep 17;130(37):12236-7. doi: 10.1021/ja8044162. Epub 2008 Aug 21. J Am Chem Soc. 2008. PMID: 18714992 Free PMC article.

3

Application of a newly identified and characterized 18-o-acyltransferase in chemoenzymatic synthesis of selected natural and nonnatural bioactive derivatives of phoslactomycins.

Ghatge MS, Palaniappan N, Alhamadsheh MM, DiBari J, Reynolds KA. Ghatge MS, et al. Among authors: alhamadsheh mm. Appl Environ Microbiol. 2009 Jun;75(11):3469-76. doi: 10.1128/AEM.02590-08. Epub 2009 Mar 20. Appl Environ Microbiol. 2009. PMID: 19304832 Free PMC article.

4

Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis.

Mo S, Sydor PK, Corre C, Alhamadsheh MM, Stanley AE, Haynes SW, Song L, Reynolds KA, Challis GL. Mo S, et al. Among authors: alhamadsheh mm. Chem Biol. 2008 Feb;15(2):137-48. doi: 10.1016/j.chembiol.2007.11.015. Chem Biol. 2008. PMID: 18291318

5

Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH.

Sachdeva S, Musayev FN, Alhamadsheh MM, Scarsdale JN, Wright HT, Reynolds KA. Sachdeva S, et al. Among authors: alhamadsheh mm. Chem Biol. 2008 Apr;15(4):402-12. doi: 10.1016/j.chembiol.2008.03.007. Chem Biol. 2008. PMID: 18420147

6

Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH).

Alhamadsheh MM, Waters NC, Huddler DP, Kreishman-Deitrick M, Florova G, Reynolds KA. Alhamadsheh MM, et al. Bioorg Med Chem Lett. 2007 Feb 15;17(4):879-83. doi: 10.1016/j.bmcl.2006.11.067. Epub 2006 Dec 1. Bioorg Med Chem Lett. 2007. PMID: 17189694

7

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes.

Alhamadsheh MM, Musayev F, Komissarov AA, Sachdeva S, Wright HT, Scarsdale N, Florova G, Reynolds KA. Alhamadsheh MM, et al. Chem Biol. 2007 May;14(5):513-24. doi: 10.1016/j.chembiol.2007.03.013. Chem Biol. 2007. PMID: 17524982

8

Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates.

Sachdeva S, Musayev F, Alhamadsheh MM, Neel Scarsdale J, Tonie Wright H, Reynolds KA. Sachdeva S, et al. Among authors: alhamadsheh mm. Bioorg Chem. 2008 Apr;36(2):85-90. doi: 10.1016/j.bioorg.2007.11.001. Epub 2007 Dec 21. Bioorg Chem. 2008. PMID: 18096200 Free PMC article.

9

Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors.

Alhamadsheh MM, Waters NC, Sachdeva S, Lee P, Reynolds KA. Alhamadsheh MM, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5. doi: 10.1016/j.bmcl.2008.10.097. Epub 2008 Oct 25. Bioorg Med Chem Lett. 2008. PMID: 18996691

10

Antimalarial activity of natural and synthetic prodiginines.

Papireddy K, Smilkstein M, Kelly JX, Shweta, Salem SM, Alhamadsheh M, Haynes SW, Challis GL, Reynolds KA. Papireddy K, et al. J Med Chem. 2011 Aug 11;54(15):5296-306. doi: 10.1021/jm200543y. Epub 2011 Jul 8. J Med Chem. 2011. PMID: 21736388 Free PMC article.

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