Reynolds KA - Search Results

1

Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis.

Alhamadsheh MM, Palaniappan N, Daschouduri S, Reynolds KA. Alhamadsheh MM, et al. Among authors: reynolds ka. J Am Chem Soc. 2007 Feb 21;129(7):1910-1. doi: 10.1021/ja068818t. Epub 2007 Jan 27. J Am Chem Soc. 2007. PMID: 17256943 Free PMC article.

2

Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster.

Palaniappan N, Kim BS, Sekiyama Y, Osada H, Reynolds KA. Palaniappan N, et al. Among authors: reynolds ka. J Biol Chem. 2003 Sep 12;278(37):35552-7. doi: 10.1074/jbc.M305082200. Epub 2003 Jun 20. J Biol Chem. 2003. PMID: 12819191 Free article.

3

Genetic manipulation of the biosynthetic process leading to phoslactomycins, potent protein phosphatase 2A inhibitors.

Ghatge M, Palaniappan N, Das Choudhuri S, Reynolds K. Ghatge M, et al. J Ind Microbiol Biotechnol. 2006 Jul;33(7):589-99. doi: 10.1007/s10295-006-0116-1. Epub 2006 Apr 12. J Ind Microbiol Biotechnol. 2006. PMID: 16609856 Review.

4

Production of hygromycin A analogs in Streptomyces hygroscopicus NRRL 2388 through identification and manipulation of the biosynthetic gene cluster.

Palaniappan N, Ayers S, Gupta S, Habib el-S, Reynolds KA. Palaniappan N, et al. Among authors: reynolds ka. Chem Biol. 2006 Jul;13(7):753-64. doi: 10.1016/j.chembiol.2006.05.013. Chem Biol. 2006. PMID: 16873023

5

Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH).

Alhamadsheh MM, Waters NC, Huddler DP, Kreishman-Deitrick M, Florova G, Reynolds KA. Alhamadsheh MM, et al. Among authors: reynolds ka. Bioorg Med Chem Lett. 2007 Feb 15;17(4):879-83. doi: 10.1016/j.bmcl.2006.11.067. Epub 2006 Dec 1. Bioorg Med Chem Lett. 2007. PMID: 17189694

6

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes.

Alhamadsheh MM, Musayev F, Komissarov AA, Sachdeva S, Wright HT, Scarsdale N, Florova G, Reynolds KA. Alhamadsheh MM, et al. Among authors: reynolds ka. Chem Biol. 2007 May;14(5):513-24. doi: 10.1016/j.chembiol.2007.03.013. Chem Biol. 2007. PMID: 17524982

7

Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates.

Sachdeva S, Musayev F, Alhamadsheh MM, Neel Scarsdale J, Tonie Wright H, Reynolds KA. Sachdeva S, et al. Among authors: reynolds ka. Bioorg Chem. 2008 Apr;36(2):85-90. doi: 10.1016/j.bioorg.2007.11.001. Epub 2007 Dec 21. Bioorg Chem. 2008. PMID: 18096200 Free PMC article.

8

Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis.

Mo S, Sydor PK, Corre C, Alhamadsheh MM, Stanley AE, Haynes SW, Song L, Reynolds KA, Challis GL. Mo S, et al. Among authors: reynolds ka. Chem Biol. 2008 Feb;15(2):137-48. doi: 10.1016/j.chembiol.2007.11.015. Chem Biol. 2008. PMID: 18291318

9

Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH.

Sachdeva S, Musayev FN, Alhamadsheh MM, Scarsdale JN, Wright HT, Reynolds KA. Sachdeva S, et al. Among authors: reynolds ka. Chem Biol. 2008 Apr;15(4):402-12. doi: 10.1016/j.chembiol.2008.03.007. Chem Biol. 2008. PMID: 18420147

10

Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis.

Turos E, Revell KD, Ramaraju P, Gergeres DA, Greenhalgh K, Young A, Sathyanarayan N, Dickey S, Lim D, Alhamadsheh MM, Reynolds K. Turos E, et al. Bioorg Med Chem. 2008 Jul 1;16(13):6501-8. doi: 10.1016/j.bmc.2008.05.032. Epub 2008 May 17. Bioorg Med Chem. 2008. PMID: 18524602 Free PMC article.

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