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Page 1
Antibody-maytansinoid conjugates designed to bypass multidrug resistance.
Kovtun YV, Audette CA, Mayo MF, Jones GE, Doherty H, Maloney EK, Erickson HK, Sun X, Wilhelm S, Ab O, Lai KC, Widdison WC, Kellogg B, Johnson H, Pinkas J, Lutz RJ, Singh R, Goldmacher VS, Chari RV. Kovtun YV, et al. Among authors: chari rv. Cancer Res. 2010 Mar 15;70(6):2528-37. doi: 10.1158/0008-5472.CAN-09-3546. Epub 2010 Mar 2. Cancer Res. 2010. PMID: 20197459
Eradication of large colon tumor xenografts by targeted delivery of maytansinoids.
Liu C, Tadayoni BM, Bourret LA, Mattocks KM, Derr SM, Widdison WC, Kedersha NL, Ariniello PD, Goldmacher VS, Lambert JM, Blättler WA, Chari RV. Liu C, et al. Among authors: chari rv. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8618-23. doi: 10.1073/pnas.93.16.8618. Proc Natl Acad Sci U S A. 1996. PMID: 8710920 Free PMC article.
Folate-maytansinoids: target-selective drugs of low molecular weight.
Ladino CA, Chari RV, Bourret LA, Kedersha NL, Goldmacher VS. Ladino CA, et al. Among authors: chari rv. Int J Cancer. 1997 Dec 10;73(6):859-64. doi: 10.1002/(sici)1097-0215(19971210)73:6<859::aid-ijc16>3.0.co;2-#. Int J Cancer. 1997. PMID: 9399666
Semisynthetic maytansine analogues for the targeted treatment of cancer.
Widdison WC, Wilhelm SD, Cavanagh EE, Whiteman KR, Leece BA, Kovtun Y, Goldmacher VS, Xie H, Steeves RM, Lutz RJ, Zhao R, Wang L, Blättler WA, Chari RV. Widdison WC, et al. Among authors: chari rv. J Med Chem. 2006 Jul 13;49(14):4392-408. doi: 10.1021/jm060319f. J Med Chem. 2006. PMID: 16821799
Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate.
Lewis Phillips GD, Li G, Dugger DL, Crocker LM, Parsons KL, Mai E, Blättler WA, Lambert JM, Chari RV, Lutz RJ, Wong WL, Jacobson FS, Koeppen H, Schwall RH, Kenkare-Mitra SR, Spencer SD, Sliwkowski MX. Lewis Phillips GD, et al. Among authors: chari rv. Cancer Res. 2008 Nov 15;68(22):9280-90. doi: 10.1158/0008-5472.CAN-08-1776. Cancer Res. 2008. PMID: 19010901
60 results