Collins I - Search Results

1

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera.

Davies TG, Verdonk ML, Graham B, Saalau-Bethell S, Hamlett CC, McHardy T, Collins I, Garrett MD, Workman P, Woodhead SJ, Jhoti H, Barford D. Davies TG, et al. Among authors: collins i. J Mol Biol. 2007 Mar 30;367(3):882-94. doi: 10.1016/j.jmb.2007.01.004. Epub 2007 Jan 9. J Mol Biol. 2007. PMID: 17275837

2

Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors.

Chau NM, Rogers P, Aherne W, Carroll V, Collins I, McDonald E, Workman P, Ashcroft M. Chau NM, et al. Among authors: collins i. Cancer Res. 2005 Jun 1;65(11):4918-28. doi: 10.1158/0008-5472.CAN-04-4453. Cancer Res. 2005. PMID: 15930314

3

Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors.

Collins I, Garrett MD. Collins I, et al. Curr Opin Pharmacol. 2005 Aug;5(4):366-73. doi: 10.1016/j.coph.2005.04.009. Curr Opin Pharmacol. 2005. PMID: 15964238 Review.

4

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B.

Collins I, Caldwell J, Fonseca T, Donald A, Bavetsias V, Hunter LJ, Garrett MD, Rowlands MG, Aherne GW, Davies TG, Berdini V, Woodhead SJ, Davis D, Seavers LC, Wyatt PG, Workman P, McDonald E. Collins I, et al. Bioorg Med Chem. 2006 Feb 15;14(4):1255-73. doi: 10.1016/j.bmc.2005.09.055. Epub 2005 Oct 24. Bioorg Med Chem. 2006. PMID: 16249095

5

Identification of small-molecule inhibitors of protein kinase B (PKB/AKT) in an AlphaScreenTM high-throughput screen.

Burns S, Travers J, Collins I, Rowlands MG, Newbatt Y, Thompson N, Garrett MD, Workman P, Aherne W. Burns S, et al. Among authors: collins i. J Biomol Screen. 2006 Oct;11(7):822-7. doi: 10.1177/1087057106290992. Epub 2006 Aug 10. J Biomol Screen. 2006. PMID: 16902245

6

Identification of novel keratinocyte differentiation modulating compounds by high-throughput screening.

Honma M, Stubbs M, Collins I, Workman P, Aherne W, Watt FM. Honma M, et al. Among authors: collins i. J Biomol Screen. 2006 Dec;11(8):977-84. doi: 10.1177/1087057106292556. Epub 2006 Nov 7. J Biomol Screen. 2006. PMID: 17092913

7

New approaches to molecular cancer therapeutics.

Collins I, Workman P. Collins I, et al. Nat Chem Biol. 2006 Dec;2(12):689-700. doi: 10.1038/nchembio840. Nat Chem Biol. 2006. PMID: 17108987 Review.

8

A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation.

Hardcastle A, Tomlin P, Norris C, Richards J, Cordwell M, Boxall K, Rowlands M, Jones K, Collins I, McDonald E, Workman P, Aherne W. Hardcastle A, et al. Among authors: collins i. Mol Cancer Ther. 2007 Mar;6(3):1112-22. doi: 10.1158/1535-7163.MCT-06-0496. Mol Cancer Ther. 2007. PMID: 17363504

9

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.

Donald A, McHardy T, Rowlands MG, Hunter LJ, Davies TG, Berdini V, Boyle RG, Aherne GW, Garrett MD, Collins I. Donald A, et al. Among authors: collins i. J Med Chem. 2007 May 17;50(10):2289-92. doi: 10.1021/jm0700924. Epub 2007 Apr 24. J Med Chem. 2007. PMID: 17451235

10

CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?

Antoni L, Sodha N, Collins I, Garrett MD. Antoni L, et al. Among authors: collins i. Nat Rev Cancer. 2007 Dec;7(12):925-36. doi: 10.1038/nrc2251. Nat Rev Cancer. 2007. PMID: 18004398 Review.

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