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Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors.
El Abdellaoui H, Varaprasad CV, Barawkar D, Chakravarty S, Maderna A, Tam R, Chen H, Allan M, Wu JZ, Appleby T, Yan S, Zhang W, Lang S, Yao N, Hamatake R, Hong Z. El Abdellaoui H, et al. Among authors: yan s. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5561-6. doi: 10.1016/j.bmcl.2006.08.048. Epub 2006 Aug 24. Bioorg Med Chem Lett. 2006. PMID: 16934458
Identification of novel, selective and potent Chk2 inhibitors.
Larson G, Yan S, Chen H, Rong F, Hong Z, Wu JZ. Larson G, et al. Among authors: yan s. Bioorg Med Chem Lett. 2007 Jan 1;17(1):172-5. doi: 10.1016/j.bmcl.2006.09.067. Epub 2006 Oct 10. Bioorg Med Chem Lett. 2007. PMID: 17035018
Isothiazoles as active-site inhibitors of HCV NS5B polymerase.
Yan S, Appleby T, Gunic E, Shim JH, Tasu T, Kim H, Rong F, Chen H, Hamatake R, Wu JZ, Hong Z, Yao N. Yan S, et al. Bioorg Med Chem Lett. 2007 Jan 1;17(1):28-33. doi: 10.1016/j.bmcl.2006.10.002. Epub 2006 Oct 5. Bioorg Med Chem Lett. 2007. PMID: 17049853
Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity.
Lee J, Han KC, Kang JH, Pearce LL, Lewin NE, Yan S, Benzaria S, Nicklaus MC, Blumberg PM, Marquez VE. Lee J, et al. Among authors: yan s. J Med Chem. 2001 Dec 6;44(25):4309-12. doi: 10.1021/jm0103965. J Med Chem. 2001. PMID: 11728178
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