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Page 1
Preactivated oxazaphosphorines designed for isophosphoramide mustard delivery as bulk form or nanoassemblies: synthesis and proof of concept.
Skarbek C, Lesueur LL, Chapuis H, Deroussent A, Pioche Durieu C, Daville A, Caron J, Rivard M, Martens T, Bertrand JR, Le Cam E, Vassal G, Couvreur P, Desmaele D, Paci A. Skarbek C, et al. Among authors: deroussent a. J Med Chem. 2015 Jan 22;58(2):705-17. doi: 10.1021/jm501224x. Epub 2014 Dec 23. J Med Chem. 2015. PMID: 25494842
Simultaneous quantification of preactivated ifosfamide derivatives and of 4-hydroxyifosfamide by high performance liquid chromatography-tandem mass spectrometry in mouse plasma and its application to a pharmacokinetic study.
Deroussent A, Skarbek C, Maury A, Chapuis H, Daudigeos-Dubus E, Le Dret L, Durand S, Couvreur P, Desmaële D, Paci A. Deroussent A, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jun 15;992:30-5. doi: 10.1016/j.jchromb.2015.04.025. Epub 2015 Apr 20. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 25939095
1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.
Naret T, Khelifi I, Provot O, Bignon J, Levaique H, Dubois J, Souce M, Kasselouri A, Deroussent A, Paci A, Varela PF, Gigant B, Alami M, Hamze A. Naret T, et al. Among authors: deroussent a. J Med Chem. 2019 Feb 28;62(4):1902-1916. doi: 10.1021/acs.jmedchem.8b01386. Epub 2018 Dec 21. J Med Chem. 2019. PMID: 30525602
Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice.
Reddy LH, Khoury H, Paci A, Deroussent A, Ferreira H, Dubernet C, Declèves X, Besnard M, Chacun H, Lepêtre-Mouelhi S, Desmaële D, Rousseau B, Laugier C, Cintrat JC, Vassal G, Couvreur P. Reddy LH, et al. Among authors: deroussent a. Drug Metab Dispos. 2008 Aug;36(8):1570-7. doi: 10.1124/dmd.108.020735. Epub 2008 May 12. Drug Metab Dispos. 2008. PMID: 18474674
New ifosfamide analogs designed for lower associated neurotoxicity and nephrotoxicity with modified alkylating kinetics leading to enhanced in vitro anticancer activity.
Storme T, Deroussent A, Mercier L, Prost E, Re M, Munier F, Martens T, Bourget P, Vassal G, Royer J, Paci A. Storme T, et al. Among authors: deroussent a. J Pharmacol Exp Ther. 2009 Feb;328(2):598-609. doi: 10.1124/jpet.108.144170. Epub 2008 Nov 18. J Pharmacol Exp Ther. 2009. PMID: 19017849
Oxazaphosphorines: new therapeutic strategies for an old class of drugs.
Giraud B, Hebert G, Deroussent A, Veal GJ, Vassal G, Paci A. Giraud B, et al. Among authors: deroussent a. Expert Opin Drug Metab Toxicol. 2010 Aug;6(8):919-38. doi: 10.1517/17425255.2010.487861. Expert Opin Drug Metab Toxicol. 2010. PMID: 20446865 Review.
40 results