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Page 1
αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation.
Uboveja A, Huang Z, Buj R, Amalric A, Wang H, Tangudu NK, Cole AR, Megill E, Kantner D, Chatoff A, Ahmad H, Marcinkiewicz MM, Disharoon JA, Graff S, Dahl ES, Hempel N, Stallaert W, Sidoli S, Bitler BG, Long DT, Snyder NW, Aird KM. Uboveja A, et al. Among authors: hempel n. bioRxiv [Preprint]. 2024 Feb 11:2024.02.06.578742. doi: 10.1101/2024.02.06.578742. bioRxiv. 2024. PMID: 38370789 Free PMC article. Preprint.
GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15.
Chang C, Cheng YY, Kamlapurkar S, White SR, Tang PW, Elhaw AT, Javed Z, Aird KM, Mythreye K, Phaëton R, Hempel N. Chang C, et al. Among authors: hempel n. bioRxiv [Preprint]. 2024 Jan 29:2024.01.24.577037. doi: 10.1101/2024.01.24.577037. bioRxiv. 2024. Update in: Gynecol Oncol. 2024 Jun;185:8-16. doi: 10.1016/j.ygyno.2024.02.004 PMID: 38352432 Free PMC article. Updated. Preprint.
Heparan sulfate modifications of betaglycan promote TIMP3-dependent ectodomain shedding to fine-tune TGF-β signaling.
Choi AS, Jenkins-Lane LM, Barton W, Kumari A, Lancaster C, Raulerson C, Ji H, Altomare D, Starr MD, Whitaker R, Phaeton R, Arend R, Shtutman M, Nixon AB, Hempel N, Lee NY, Mythreye K. Choi AS, et al. Among authors: hempel n. bioRxiv [Preprint]. 2023 Aug 29:2023.08.29.555364. doi: 10.1101/2023.08.29.555364. bioRxiv. 2023. Update in: Cell Commun Signal. 2024 Feb 15;22(1):128. doi: 10.1186/s12964-024-01496-y PMID: 37693479 Free PMC article. Updated. Preprint.
Development of adaptive anoikis resistance promotes metastasis that can be overcome by CDK8/19 Mediator kinase inhibition.
Monavarian M, Page EF, Rajkarnikar R, Kumari A, Macias LQ, Massicano F, Lee NY, Sahoo S, Hempel N, Jolly MK, Ianov L, Worthey E, Singh A, Broude EV, Mythreye K. Monavarian M, et al. Among authors: hempel n. bioRxiv [Preprint]. 2023 Dec 6:2023.12.04.569970. doi: 10.1101/2023.12.04.569970. bioRxiv. 2023. PMID: 38106208 Free PMC article. Preprint.
The type III TGF-beta receptor suppresses breast cancer progression.
Dong M, How T, Kirkbride KC, Gordon KJ, Lee JD, Hempel N, Kelly P, Moeller BJ, Marks JR, Blobe GC. Dong M, et al. Among authors: hempel n. J Clin Invest. 2007 Jan;117(1):206-17. doi: 10.1172/JCI29293. Epub 2006 Dec 7. J Clin Invest. 2007. PMID: 17160136 Free PMC article.
Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma.
Cooper SJ, Zou H, Legrand SN, Marlow LA, von Roemeling CA, Radisky DC, Wu KJ, Hempel N, Margulis V, Tun HW, Blobe GC, Wood CG, Copland JA. Cooper SJ, et al. Among authors: hempel n. Oncogene. 2010 May 20;29(20):2905-15. doi: 10.1038/onc.2010.64. Epub 2010 Mar 8. Oncogene. 2010. PMID: 20208565 Free PMC article.
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