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The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease.
Huttner HB, Janich P, Köhrmann M, Jászai J, Siebzehnrubl F, Blümcke I, Suttorp M, Gahr M, Kuhnt D, Nimsky C, Krex D, Schackert G, Löwenbrück K, Reichmann H, Jüttler E, Hacke W, Schellinger PD, Schwab S, Wilsch-Bräuninger M, Marzesco AM, Corbeil D. Huttner HB, et al. Among authors: marzesco am. Stem Cells. 2008 Mar;26(3):698-705. doi: 10.1634/stemcells.2007-0639. Epub 2007 Dec 20. Stem Cells. 2008. PMID: 18096722
The intriguing links between prominin-1 (CD133), cholesterol-based membrane microdomains, remodeling of apical plasma membrane protrusions, extracellular membrane particles, and (neuro)epithelial cell differentiation.
Corbeil D, Marzesco AM, Wilsch-Bräuninger M, Huttner WB. Corbeil D, et al. Among authors: marzesco am. FEBS Lett. 2010 May 3;584(9):1659-64. doi: 10.1016/j.febslet.2010.01.050. Epub 2010 Feb 2. FEBS Lett. 2010. PMID: 20122930 Free article. Review.
Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into urine.
Florek M, Bauer N, Janich P, Wilsch-Braeuninger M, Fargeas CA, Marzesco AM, Ehninger G, Thiele C, Huttner WB, Corbeil D. Florek M, et al. Among authors: marzesco am. Cell Tissue Res. 2007 Apr;328(1):31-47. doi: 10.1007/s00441-006-0324-z. Epub 2006 Nov 16. Cell Tissue Res. 2007. PMID: 17109118
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